Technology Process of (R)-2-((4-ethylphenyl)(phenyl)methyl)-5,5-dimethyl-1,3,2-dioxaborinane
There total 3 articles about (R)-2-((4-ethylphenyl)(phenyl)methyl)-5,5-dimethyl-1,3,2-dioxaborinane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diisopropyl-carbamic acid phenylmethyl ester;
With
(4S)-2,2'-(1-Ethylpropylidene)bis<4-(1-methylethyl)-4,5-dihydrooxazole>;
In
diethyl ether;
at -78 ℃;
for 0.5h;
Inert atmosphere;
With
sec.-butyllithium;
In
diethyl ether;
at -78 ℃;
for 3.33h;
Inert atmosphere;
2-(4-ethylphenyl)-5,5-dimethyl-1,3,2-dioxaborinane;
enantioselective reaction; Further stages;
DOI:10.1021/ja412159g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: magnesium sulfate / diethyl ether / 20 h / 25 °C / Inert atmosphere
2.1: (4S)-2,2'-(1-Ethylpropylidene)bis<4-(1-methylethyl)-4,5-dihydrooxazole> / diethyl ether / 0.5 h / -78 °C / Inert atmosphere
2.2: 3.33 h / -78 °C / Inert atmosphere
With
magnesium sulfate; (4S)-2,2'-(1-Ethylpropylidene)bis<4-(1-methylethyl)-4,5-dihydrooxazole>;
In
diethyl ether;
DOI:10.1021/ja412159g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 24 h / Inert atmosphere; Reflux
2.1: (4S)-2,2'-(1-Ethylpropylidene)bis<4-(1-methylethyl)-4,5-dihydrooxazole> / diethyl ether / 0.5 h / -78 °C / Inert atmosphere
2.2: 3.33 h / -78 °C / Inert atmosphere
With
triethylamine; (4S)-2,2'-(1-Ethylpropylidene)bis<4-(1-methylethyl)-4,5-dihydrooxazole>;
In
diethyl ether; dichloromethane;
DOI:10.1021/ja412159g
