8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7c-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester

Base Information

• Chemical Name: 8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7c-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester
• CAS No.: 37469-74-2
• Molecular Formula: C₂₁H₂₇NO₅S
• Molecular Weight: 405.515
• Mol file: 37469-74-2.mol

Synonyms:

Chemical Property of 8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7c-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7c-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester

There total 1 articles about 8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7c-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[diazo-(1-methyl-1-phenyl-ethoxycarbonyl)-acetyl]-thiomorpholine-3-carboxylic acid tert-butyl ester (37469-73-1) → 8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7c-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester (37469-74-2,37469-75-3,49855-53-0)

Guidance literature:

In benzene; Irradiation;

DOI:10.1039/P19730001321

Reference yield:

8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7c-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester (37469-74-2,37469-75-3,49855-53-0) → 7c-[N'-(1-methyl-1-phenyl-ethoxycarbonyl)-hydrazinocarbonyl]-8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid tert-butyl ester (49855-55-2,49855-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / CH₂Cl₂

2: DCC / CH₂Cl₂

With hydrogenchloride; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1039/P19730001321

Reference yield:

8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7c-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester (37469-74-2,37469-75-3,49855-53-0) + methyl iodide (74-88-4) → 7-methyl-8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c,7t-dicarboxylic acid 2-tert-butyl ester 7-(1-methyl-1-phenyl-ethyl) ester

Guidance literature:

Multistep reaction; (i) KOtBu, tBuOH, (ii) /BRN= 969135/;

DOI:10.1039/P19730001321

upstream raw materials:

4-[diazo-(1-methyl-1-phenyl-ethoxycarbonyl)-acetyl]-thiomorpholine-3-carboxylic acid tert-butyl ester

Downstream raw materials:

7c-[N'-(1-methyl-1-phenyl-ethoxycarbonyl)-hydrazinocarbonyl]-8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid tert-butyl ester