C₁₂H₁₈O₈

Base Information

• Chemical Name: C₁₂H₁₈O₈
• CAS No.: 1382683-39-7
• Molecular Formula: C₁₂H₁₈O₈
• Molecular Weight: 290.27
• Mol file: 1382683-39-7.mol

Synonyms:

Chemical Property of C₁₂H₁₈O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₈O₈

There total 2 articles about C₁₂H₁₈O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + methyl L-lyxofuranoside (202119-57-1) → C12H18O8 (1382683-39-7)

Guidance literature:

With pyridine; at 20 ℃; Cooling with ice;

DOI:10.1080/00397911.2011.571805

Reference yield:

L-lyxofuranose (532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7,34436-17-4) → C12H18O8 (1382683-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 5 h / 20 °C / Cooling with ice

2: pyridine / 20 °C / Cooling with ice

With pyridine; sulfuric acid;

DOI:10.1080/00397911.2011.571805

Reference yield:

C12H18O8 (1382683-39-7) → α-elvucitabine (181785-84-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sulfuric acid / acetic acid / 5 h / 20 °C / Cooling with ice

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / Cooling with ice; Reflux

3.1: ammonia / methanol / 5 h / 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Cooling with ice

5.1: sodium hydroxide / water; dimethyl sulfoxide / 0.5 h / Cooling with ice

5.2: 2 h / 20 °C

6.1: dibutyl(pentyl)stannane; 2,2'-azobis(isobutyronitrile) / toluene / 1 h / Reflux; Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; dibutyl(pentyl)stannane; sulfuric acid; tetrabutyl ammonium fluoride; ammonia; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 6.1: Barton-McCombie deoxygenation;

DOI:10.1080/00397911.2011.571805

upstream raw materials:

L-lyxofuranose

acetic anhydride

methyl L-lyxofuranoside

Downstream raw materials:

α-elvucitabine