3β-benzoyl-5α-cholestane

Base Information

• Chemical Name: 3β-benzoyl-5α-cholestane
• CAS No.: 82871-88-3
• Molecular Formula: C₃₄H₅₂O
• Molecular Weight: 476.786
• Mol file: 82871-88-3.mol

Synonyms:

Chemical Property of 3β-benzoyl-5α-cholestane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-benzoyl-5α-cholestane

There total 4 articles about 3β-benzoyl-5α-cholestane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl]-phenyl-methanol → 3β-benzoyl-5α-cholestane (82871-88-3)

Guidance literature:

With potassium dichromate; In diethyl ether; sulfuric acid; for 2h; Yield given; Heating;

DOI:10.1021/jo00143a019

Reference yield:

dihydrocholesterone (566-88-1) → 3β-benzoyl-5α-cholestane (82871-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) DME, hexane, 15 min, 2.) 20 h

2: 1.) NaBH₄, BF₃-Et₂O, 2.) 3 N NaOH / 1.) THF, 16 h

3: Cr₂O₇K₂ / diethyl ether; aq. H₂SO₄ / 2 h / Heating

With potassium dichromate; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; In diethyl ether; sulfuric acid;

DOI:10.1021/jo00143a019

Reference yield:

benzyltriphenylphosphonium chloride (1100-88-5) → 3β-benzoyl-5α-cholestane (82871-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) DME, hexane, 15 min, 2.) 20 h

2: 1.) NaBH₄, BF₃-Et₂O, 2.) 3 N NaOH / 1.) THF, 16 h

3: Cr₂O₇K₂ / diethyl ether; aq. H₂SO₄ / 2 h / Heating

With potassium dichromate; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; In diethyl ether; sulfuric acid;

DOI:10.1021/jo00143a019

upstream raw materials:

dihydrocholesterone

benzyltriphenylphosphonium chloride

3-benzylidene-5α-cholestane

Downstream raw materials:

3α-benzoyl-3-bromo-5α-cholestane

3β-benzoyl-3-bromo-5α-cholestane

[(1R,3R,5S,8S,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10-hydroxy-1,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl]-phenyl-methanone

3-benzoylcholest-2-ene