Methyl N-fumarylphenylalaninate

Base Information

Chemical Name:Methyl N-fumarylphenylalaninate
CAS No.:105469-66-7
Molecular Formula:C₁₄H₁₅NO₅
Molecular Weight:277.277
Hs Code.:
UNII:2GR4CCC2M1
Nikkaji Number:J797.646A

Synonyms:2GR4CCC2M1;Methyl N-fumarylphenylalaninate;1-Methyl N-fumarylphenylalaninate;1-Methyl-N-fumarylphenylalaninate;UNII-2GR4CCC2M1;105469-66-7;L-Phenylalanine, N-((2E)-3-carboxy-1-oxo-2-propenyl)-, alpha-methyl ester;L-Phenylalanine, N-(3-carboxy-1-oxo-2-propenyl)-, alpha-methyl ester, (E)-;SCHEMBL10537018;SCHEMBL10537019;N-[(E)-3-(Hydroxycarbonyl)propenoyl]-L-phenylalanine methyl ester;L-PHENYLALANINE, N-((2E)-3-CARBOXY-1-OXO-2-PROPENYL)-, .ALPHA.-METHYL ESTER;L-PHENYLALANINE, N-(3-CARBOXY-1-OXO-2-PROPENYL)-, .ALPHA.-METHYL ESTER, (E)-

Suppliers and Price of Methyl N-fumarylphenylalaninate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methyl N-fumarylphenylalaninate

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:277.09502258
Heavy Atom Count:20
Complexity:385

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C(CC1=CC=CC=C1)NC(=O)C=CC(=O)O
Isomeric SMILES:COC(=O)[C@H](CC1=CC=CC=C1)NC(=O)/C=C/C(=O)O

Technology Process of Methyl N-fumarylphenylalaninate

There total 2 articles about Methyl N-fumarylphenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108-31-6
maleic anhydride

: 2577-90-4
L-phenylalanine methyl ester

: 50997-19-8,105469-66-7,125407-29-6,130049-42-2
N-(cis-β-Carboxy-acryloyl)-(L)-phenylalaninmethylester

Guidance literature:: In diethyl ether; for 0.5h;
DOI:10.1007/BF00816859

Reference yield: 89.0%

: 108-31-6
maleic anhydride

: 2577-90-4,15028-44-1,21685-51-8
(D)-Phenylalaninmethylester

: 50997-19-8,105469-66-7,125407-29-6,130049-42-2
N-(cis-β-Carboxy-acryloyl)-(D)-phenylalaninmethylester

Guidance literature:: In diethyl ether; for 0.5h;
DOI:10.1007/BF00816859

Reference yield:

: 50997-19-8,105469-66-7,125407-29-6,130049-42-2
N-(cis-β-Carboxy-acryloyl)-(D)-phenylalaninmethylester

: 144965-45-7,144965-46-8,144965-47-9,144965-48-0,144965-49-1
N-Benzyl-α-aspartyl-(β-benzyl)-(D)-phenylalaninmethylester

Guidance literature:: Multi-step reaction with 2 steps

1: 61.5 percent / triethylamine / CH₂Cl₂ / 1) reflux, 72 h, 2) room temp., 48 h

2: 82.1 percent / acetonitrile / 75 h / 25 - 30 °C

With triethylamine; In dichloromethane; acetonitrile;
DOI:10.1007/BF00816859