1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

Base Information

Chemical Name:1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole
CAS No.:126916-45-8
Molecular Formula:C₁₃H₁₄F₂N₄O
Molecular Weight:280.277
Hs Code.:

Synonyms:

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Chemical Property of 1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

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Technology Process of 1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

There total 12 articles about 1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126918-20-5,132563-67-8,138457-41-7
(2R^*,3R^*)-2-(2,4-Difluorophenyl)-1,2,3-butanetriol

: 126916-45-8,132507-79-0,138457-44-0
1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / pyridine / 0.5 h / 0 °C

2: dimethylformamide / 2 h / 65 - 70 °C

3: 6 h / 0 °C

4: NaOH / methanol / 0.25 h / Ambient temperature

5: 1) methanesulfonyl chloride, pyridine, 2) NaN₃, NH₄Cl / 1) rt, 2 h, 2) DMF, 115 deg C, 15 h

6: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

7: benzene / 3 h / Heating

With pyridine; sodium hydroxide; sodium azide; hydrogen; ammonium chloride; methanesulfonyl chloride; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.38.2476

Reference yield:

: 126918-19-2,132563-82-7
(2S,3S)-2-(2,4-Difluoro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-butane-1,2-diol

: 126916-45-8,132507-79-0,138457-44-0
1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 8 steps

1: p-toluenesulfonic acid / methanol / 0.5 h / Ambient temperature

2: 96 percent / pyridine / 0.5 h / 0 °C

3: dimethylformamide / 2 h / 65 - 70 °C

4: 6 h / 0 °C

5: NaOH / methanol / 0.25 h / Ambient temperature

6: 1) methanesulfonyl chloride, pyridine, 2) NaN₃, NH₄Cl / 1) rt, 2 h, 2) DMF, 115 deg C, 15 h

7: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

8: benzene / 3 h / Heating

With pyridine; sodium hydroxide; sodium azide; hydrogen; ammonium chloride; toluene-4-sulfonic acid; methanesulfonyl chloride; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.38.2476

Reference yield:

: 126918-21-6,132563-68-9
(2R^*,3R^*)-2-(2,4-Difluorophenyl)-1,3-bis(methanesulfonyloxy)-2-butanol

: 126916-45-8,132507-79-0,138457-44-0
1-[(4R,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylformamide / 2 h / 65 - 70 °C

2: 6 h / 0 °C

3: NaOH / methanol / 0.25 h / Ambient temperature

4: 1) methanesulfonyl chloride, pyridine, 2) NaN₃, NH₄Cl / 1) rt, 2 h, 2) DMF, 115 deg C, 15 h

5: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

6: benzene / 3 h / Heating

With pyridine; sodium hydroxide; sodium azide; hydrogen; ammonium chloride; methanesulfonyl chloride; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.38.2476