2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Base Information

Chemical Name:2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester
CAS No.:108337-89-9
Molecular Formula:C₂₆H₂₈F₃N₃O₄
Molecular Weight:503.521
Hs Code.:

2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

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Chemical Property of 2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

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Technology Process of 2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

There total 6 articles about 2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85148-26-1
3-chloro-5-(trifluoromethyl)pyridine

: 108337-89-9
2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2) KMnO₄ / 1) Pd(PPh₃)4 / 1) dioxane, hexane, reflux, 2) H₂O, reflux

2: 1) NEt₃, ethyl chloroformate, 2) LiAlH₄ / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min

3: 52 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

4: propan-2-ol / 40 °C

5: dimethylformamide / 102 - 107 °C

With potassium permanganate; lithium aluminium tetrahydride; phosphoric acid; chloroformic acid ethyl ester; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1248/cpb.38.2446

Reference yield:

: 131747-59-6
(5-(trifluoromethyl)pyridin-3-yl)methanol

: 108337-89-9
2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

2: propan-2-ol / 40 °C

3: dimethylformamide / 102 - 107 °C

With phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1248/cpb.38.2446

Reference yield:

: 131747-40-5
5-(trifluoromethyl)pyridine-3-carboxylic acid

: 108337-89-9
2,6-dimethyl-4-(5-trifluoromethyl-3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NEt₃, ethyl chloroformate, 2) LiAlH₄ / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min

2: 52 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

3: propan-2-ol / 40 °C

4: dimethylformamide / 102 - 107 °C

With lithium aluminium tetrahydride; phosphoric acid; chloroformic acid ethyl ester; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1248/cpb.38.2446