85148-26-1Relevant articles and documents
Preparation method of 2-chloro-3-trifluoromethylpyridine
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Paragraph 0029-0061, (2021/01/25)
The invention discloses a preparation method of 2-chlorine- 3-trifluoromethylpyridine. The method comprises the following steps: (1), sequentially adding 2, 3, 6-trichloro-5-trifluoromethylpyridine, an acid-binding agent and a catalyst into a lower aliphatic alcohol solvent, and starting a circulating water pump to replace hydrogen in vacuum, with the addition amount of the catalyst being 0.01-0.5% of the reaction system; (2), controlling the temperature of the reductive dechlorination reaction to be -10-65 DEG C, the reaction hydrogen pressure to be 0.1-2.0 MPa and the reaction time to be 4-24 hours; and (3), filtering, rectifying and purifying the obtained reaction liquid in sequence to finish separation of corresponding products and unreacted raw materials. The preparation method of the2-chlorine-3-trifluoromethylpyridine, provided by the invention is simple in process, easy to operate and beneficial to industrial production, the obtained product is high in purity, the purity is greater than 98%, a plurality of useful products are produced at one time, and on the basis of the selectivity of the useful products, the selectivity is 95%, the conversion rate of a single raw material is over 95%, and the production cost is low.
Efficient indium-mediated dehalogenation of aromatics in ionic liquid media
Canete, Alvaro F.,Salas, Cristian O.,Zacconi, Flavia C.
, p. 398 - 407 (2013/03/13)
An efficient indium-mediated dehalogenation reaction of haloaromatics and haloheteroaromatics in ionic liquids has been studied. This method is simple and effective in the presence of [bmim]Br. Furthermore, this methodology is environmentally friendly compared with conventional ones.
PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS
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Page/Page column 28, (2008/06/13)
The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.
