Technology Process of 3,5-Dimethoxy-(7S)-<7-(2)H>benzyl tosylate
There total 5 articles about 3,5-Dimethoxy-(7S)-<7-(2)H>benzyl tosylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-Butyllithium, 2.) D2O (99.8 percent (2)H) / 1.) THF/hexane, -70 deg C, 1 h, 2.) 2 h, room temp.
2: 88.1 percent / HgO/HgCl2 / methanol; H2O / 2 h / 80 - 85 °C
3: 83.4 percent / 1.) (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 1.) 15 h, room temp., 2.) reflux, 1 h
4: 1.) NaH/mineral oil
With
n-butyllithium; (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane; water-d2; sodium hydride; mercury dichloride; mercury(II) oxide; mineral oil;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/jo00168a027
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75.8 percent / HCl gas / CHCl3 / 18 h / Ambient temperature
2: 1.) n-Butyllithium, 2.) D2O (99.8 percent (2)H) / 1.) THF/hexane, -70 deg C, 1 h, 2.) 2 h, room temp.
3: 88.1 percent / HgO/HgCl2 / methanol; H2O / 2 h / 80 - 85 °C
4: 83.4 percent / 1.) (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 1.) 15 h, room temp., 2.) reflux, 1 h
5: 1.) NaH/mineral oil
With
hydrogenchloride; n-butyllithium; (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane; water-d2; sodium hydride; mercury dichloride; mercury(II) oxide; mineral oil;
In
tetrahydrofuran; methanol; chloroform; water;
DOI:10.1021/jo00168a027
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 83.4 percent / 1.) (+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 1.) 15 h, room temp., 2.) reflux, 1 h
2: 1.) NaH/mineral oil
With
(+)-α-Pinanyl-9-borabicyclo<3.3.1>nonane; sodium hydride; mineral oil;
In
tetrahydrofuran;
DOI:10.1021/jo00168a027
