3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol

Base Information

• Chemical Name: 3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol
• CAS No.: 136179-18-5
• Molecular Formula: C₁₃H₂₀O₅
• Molecular Weight: 256.299
• Mol file: 136179-18-5.mol

Synonyms:

Chemical Property of 3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol

There total 4 articles about 3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(3-Methoxyphenyl)-2-propen-1-ol (125617-35-8) → 3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol (136179-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: vanadyl acetoacetate, t-butyl hydroperoxide / benzene; toluene / 3 h / 60 °C

2: p-toluenesulphonic acid

With tert.-butylhydroperoxide; vanadyl acetoacetonate; toluene-4-sulfonic acid; In toluene; benzene;

Reference yield:

trans-3-methoxycinnamic acid (6099-04-3,17570-26-2) → 3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol (136179-18-5)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂ / CH₂Cl₂ / Ambient temperature

2: NaBH₄, Na₂CO₃ / acetonitrile; H₂O / Ambient temperature

3: vanadyl acetoacetate, t-butyl hydroperoxide / benzene; toluene / 3 h / 60 °C

4: p-toluenesulphonic acid

With tert.-butylhydroperoxide; sodium tetrahydroborate; thionyl chloride; vanadyl acetoacetonate; sodium carbonate; toluene-4-sulfonic acid; In dichloromethane; water; toluene; acetonitrile; benzene;

Reference yield:

(E)-3-methoxycinnamoyl chloride (15851-92-0,56030-38-7) → 3-(2-Methoxy-ethoxy)-3-(3-methoxy-phenyl)-propane-1,2-diol (136179-18-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄, Na₂CO₃ / acetonitrile; H₂O / Ambient temperature

2: vanadyl acetoacetate, t-butyl hydroperoxide / benzene; toluene / 3 h / 60 °C

3: p-toluenesulphonic acid

With tert.-butylhydroperoxide; sodium tetrahydroborate; vanadyl acetoacetonate; sodium carbonate; toluene-4-sulfonic acid; In water; toluene; acetonitrile; benzene;

upstream raw materials:

2-methoxy-ethanol

rac-((3-(3-methoxy)phenyl)oxiran-2-yl)methanol

(E)-3-(3-Methoxyphenyl)-2-propen-1-ol

trans-3-methoxycinnamic acid

Downstream raw materials:

4-(α(2-methoxyethoxy)3-methoxybenzyl)-2,2-dimethyldioxolane