1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline
• CAS No.: 23824-24-0
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 23824-24-0.mol

Synonyms:

Chemical Property of 1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline

Chemical Property:

• Melting Point: >168°C (dec.)
• Boiling Point: 341.9±42.0 °C(Predicted)
• PKA: 9.79±0.40(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Sparingly)

Purity/Quality:

99% ^*data from raw suppliers

1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline

There total 2 articles about 1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Phenylephrine (1477-63-0) → 2-Methyl-4,6-dihydroxy-1,2,3,4-tetrahydroisoquinoline (23824-24-0)

Guidance literature:

In ethanol; Yield given; Heating;

DOI:10.1007/BF00760706

Reference yield:

→ 2-Methyl-4,6-dihydroxy-1,2,3,4-tetrahydroisoquinoline (23824-24-0)

Guidance literature:

Verb. /Z3532512171/, HCHO/H20, Δ;

Reference yield: 74.0%

N-methyl-4,6-dihydroxy-1,2,3,4-tetrahydroisoquinoline (23824-24-0) → N-methyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline (14097-39-3)

Guidance literature:

With perchloric acid; hydrogen; palladium on activated charcoal; In methanol; acetic acid; for 96h; under 2068.6 Torr;

DOI:10.1021/jo00288a048

upstream raw materials:

formaldehyd

Phenylephrine

Downstream raw materials:

N-methyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline

Refernces