C₂₁H₂₄O₅

Base Information

• Chemical Name: C₂₁H₂₄O₅
• CAS No.: 1279711-69-1
• Molecular Formula: C₂₁H₂₄O₅
• Molecular Weight: 356.419
• Mol file: 1279711-69-1.mol

Synonyms:

Chemical Property of C₂₁H₂₄O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₄O₅

There total 5 articles about C₂₁H₂₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S)-3-(benzyloxy)-2-(((4-methoxybenzyl)oxy)methyl)-3,4-dihydro-2H-pyran (1279711-35-1) → C21H24O5 (1279711-69-1)

Guidance literature:

With 3,3-dimethyldioxirane; In dichloromethane; at -55 ℃; for 48h;

DOI:10.1021/jo102382r

Reference yield:

(4aR,8R,8aS)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-ol (312623-79-3) → C21H24O5 (1279711-69-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.5 h / Reflux

3.1: borane-THF / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 16 h / -78 °C / Inert atmosphere

4.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

5.1: 3,3-dimethyldioxirane / dichloromethane / 48 h / -55 °C

With borane-THF; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; 3,3-dimethyldioxirane; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1021/jo102382r

Reference yield:

C16H18O5S2 (1279711-78-2) → C21H24O5 (1279711-69-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.5 h / Reflux

2.1: borane-THF / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 16 h / -78 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

4.1: 3,3-dimethyldioxirane / dichloromethane / 48 h / -55 °C

With borane-THF; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; 3,3-dimethyldioxirane; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1021/jo102382r

upstream raw materials:

(4aR,8R,8aS)-2-(4-methoxyphenyl)-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3]dioxin-8-ol

C₁₆H₁₈O₅S₂

3-deoxy-4,6-O-p-methoxybenzylidene-D-glucal

C₁₄H₁₈O₄

Downstream raw materials:

4-O-benzyl-1,3-dideoxy-1R-deutero-6-O-p-methoxybenzyl-D-mannopyranose