Technology Process of (R)-4-[(4S,5S,6R)-6-(2-Benzyloxy-ethyl)-5-methoxy-2,2-dimethyl-[1,3]dioxan-4-yl]-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexan-1-ol
There total 22 articles about (R)-4-[(4S,5S,6R)-6-(2-Benzyloxy-ethyl)-5-methoxy-2,2-dimethyl-[1,3]dioxan-4-yl]-6-(tert-butyl-diphenyl-silanyloxy)-2-methyl-hexan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 88 percent / NaH / 1,2-dimethoxy-ethane / 60 °C
2: 92 percent / amberlite 1R-120, H2O / 100 °C
3: 80 percent / toluene / 25 °C
4: camphorsulfonic acid / benzene / 25 °C
5: 1.) cuprous iodide / 1) -40 deg C, THF; 2) -40 deg C, 4 h
6: 90 percent / aq. HCl / ethane-1,2-diol / 25 °C
7: 98 percent / LAH / diethyl ether / 0 °C
8: 80 percent / imidazole / dimethylformamide / 25 °C
9: 98 percent / camphorsulfonic acid / acetone
10: 1.) borane, 2.) NaOH-H2O2 / 1) THF, 0 deg C
With
1H-imidazole; hydrogenchloride; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; amberlite 1R-120; camphor-10-sulfonic acid; borane; water; dihydrogen peroxide; sodium hydride;
In
1,2-dimethoxyethane; diethyl ether; ethylene glycol; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1021/ja00395a044
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 88 percent / NaH / 1,2-dimethoxy-ethane / 60 °C
2: 92 percent / amberlite 1R-120, H2O / 100 °C
3: 80 percent / toluene / 25 °C
4: camphorsulfonic acid / benzene / 25 °C
5: 1.) cuprous iodide / 1) -40 deg C, THF; 2) -40 deg C, 4 h
6: 90 percent / aq. HCl / ethane-1,2-diol / 25 °C
7: 98 percent / LAH / diethyl ether / 0 °C
8: 80 percent / imidazole / dimethylformamide / 25 °C
9: 98 percent / camphorsulfonic acid / acetone
10: 1.) borane, 2.) NaOH-H2O2 / 1) THF, 0 deg C
With
1H-imidazole; hydrogenchloride; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; amberlite 1R-120; camphor-10-sulfonic acid; borane; water; dihydrogen peroxide; sodium hydride;
In
1,2-dimethoxyethane; diethyl ether; ethylene glycol; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1021/ja00395a044
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 92 percent / amberlite 1R-120, H2O / 100 °C
2: 80 percent / toluene / 25 °C
3: camphorsulfonic acid / benzene / 25 °C
4: 1.) cuprous iodide / 1) -40 deg C, THF; 2) -40 deg C, 4 h
5: 90 percent / aq. HCl / ethane-1,2-diol / 25 °C
6: 98 percent / LAH / diethyl ether / 0 °C
7: 80 percent / imidazole / dimethylformamide / 25 °C
8: 98 percent / camphorsulfonic acid / acetone
9: 1.) borane, 2.) NaOH-H2O2 / 1) THF, 0 deg C
With
1H-imidazole; hydrogenchloride; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; amberlite 1R-120; camphor-10-sulfonic acid; borane; water; dihydrogen peroxide;
In
diethyl ether; ethylene glycol; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1021/ja00395a044
