Technology Process of tert-butyl 7-amino-2-azaspiro[3.5]nonane-2-carboxylate
There total 7 articles about tert-butyl 7-amino-2-azaspiro[3.5]nonane-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; ammonium acetate;
In
isopropyl alcohol;
at -20 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / toluene / 20 °C
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 - -30 °C / Inert atmosphere
2.2: 0.5 h / -78 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
4.1: trifluoromethylsulfonic anhydride / acetonitrile / 0.5 h / -30 °C
4.2: 1.5 h / 80 °C
5.1: palladium on activated charcoal; hydrogen; triethylamine / methanol / 80 °C / Autoclave
6.1: toluene-4-sulfonic acid / water; acetone / 45 °C
7.1: ammonium acetate; sodium tetrahydroborate / isopropyl alcohol / 1 h / -20 - 20 °C
With
sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; trifluoromethylsulfonic anhydride; palladium on activated charcoal; ammonium acetate; hydrogen; toluene-4-sulfonic acid; triethylamine; diisopropylamine;
In
tetrahydrofuran; methanol; water; isopropyl alcohol; acetone; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 - -30 °C / Inert atmosphere
1.2: 0.5 h / -78 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.1: trifluoromethylsulfonic anhydride / acetonitrile / 0.5 h / -30 °C
3.2: 1.5 h / 80 °C
4.1: palladium on activated charcoal; hydrogen; triethylamine / methanol / 80 °C / Autoclave
5.1: toluene-4-sulfonic acid / water; acetone / 45 °C
6.1: ammonium acetate; sodium tetrahydroborate / isopropyl alcohol / 1 h / -20 - 20 °C
With
sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; trifluoromethylsulfonic anhydride; palladium on activated charcoal; ammonium acetate; hydrogen; toluene-4-sulfonic acid; triethylamine; diisopropylamine;
In
tetrahydrofuran; methanol; water; isopropyl alcohol; acetone; acetonitrile;
