1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol

Base Information

• Chemical Name: 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol
• CAS No.: 1256546-72-1
• Molecular Formula: C10H18O4
• Molecular Weight: 202.251
• Hs Code.: 2932990090
• Mol file: 1256546-72-1.mol

Synonyms:1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol;1,4-Dioxaspiro[4,5]decane-8,8-diMethanol

Chemical Property of 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol

Chemical Property:

• Boiling Point: 347.2±17.0 °C(Predicted)
• PKA: 14.69±0.10(Predicted)
• PSA: 58.92000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 0.27450
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1,4-Dioxaspiro[4.5]decane-8,8-dimethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol

There total 9 articles about 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

8,8-diethyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate (1256546-71-0) → [8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol (1256546-72-1)

Guidance literature:

8,8-diethyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 15 ℃;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield: 40.0%

8-ethyl 8-methyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate (340022-79-9) → [8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol (1256546-72-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 50 - 70 ℃; for 1h;

Reference yield:

4-oxo-cyclohexane-1,1-dicarboxylic acid diethyl ester (55704-60-4) → [8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol (1256546-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / benzene / 48 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice

2.2: 1.5 h / -5 - 30 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

upstream raw materials:

8,8-diethyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate

4-oxo-cyclohexane-1,1-dicarboxylic acid diethyl ester

pentane-1,3,3,5-tetracarboxylic acid-3,3-diethyl ester

ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

Downstream raw materials:

(4-oxocyclohexane-1,1-diyl)bis(methylene) bis(4-methylbenzenesulfonate)

N-[7-(chloromethyl)-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-7-(hydroxymethyl)-4-oxo-3-(phenylmethoxy)-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(hydroxymethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Refernces

• 1、 -. "ETHANEDIAMINE-HETEROCYCLE DERIVATIVES AS INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES". Paragraph 0793. . Retrieved 2019/09/15.
• 2、 -. "Solid dispersions containing an apoptosis-inducing agent". Page/Page column 265. . Retrieved 2019/03/15.