N--L-proline

Base Information

Chemical Name:N--L-proline
CAS No.:85304-37-6
Molecular Formula:C₃₈H₃₇N₃O₆
Molecular Weight:631.728
Hs Code.:

N-<N-(2S-2-benzamido-3-phenylpropyl)-N-(9-fluorenylmethyloxycarbonyl)aminoacetyl>-L-proline

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Suppliers and Price of N--L-proline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N--L-proline

Chemical Property:

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Technology Process of N--L-proline

There total 6 articles about N--L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85304-36-5
N--L-proline benzyl ester

: 85304-37-6
N--L-proline

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 2h; Yield given;
DOI:10.1002/jps.2600720115

Reference yield:

: 85304-32-1
N-(2S-2-benzyloxycarbonylamino-3-phenylpropyl)-N-(9-fluorenylmethyloxy-carbonyl)aminoethanol

: 85304-37-6
N--L-proline

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10percent Pd/C / acetic acid / 2 h

2: NaHCO₃ / CH₂Cl₂ / 21 h / Ambient temperature

3: CrO₃ / acetone; aq. H₂SO₄ / 1 h / Ambient temperature

4: 73 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂ / 5 deg C, 0.5 h; RT, 45 h

5: H₂ / 10percent Pd/C / acetic acid / 2 h

With chromium(VI) oxide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; sulfuric acid; acetic acid; acetone;
DOI:10.1002/jps.2600720115

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 85304-37-6
N--L-proline

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂ / 5 deg C, 0.5 h; RT, 45 h

2: H₂ / 10percent Pd/C / acetic acid / 2 h

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; acetic acid;
DOI:10.1002/jps.2600720115