Cefprozil, (Z)-

Base Information

• Chemical Name: Cefprozil, (Z)-
• CAS No.: 114876-72-1
• Molecular Formula: C₁₈H₁₉N₃O₅S*H₂O
• Molecular Weight: 407.447
• UNII: 358K60B00H
• Wikidata: Q27256443
• NCI Thesaurus Code: C80090
• Mol file: 114876-72-1.mol

Synonyms:Cefprozil, (Z)-;114876-72-1;UNII-358K60B00H;358K60B00H;Cefprozil (Z)-Isomer;(6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(Z)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate;(Z)-cefprozil hydrate;CEFPROZIL, Z-ISOMER;SCHEMBL37022;Q27256443;5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7-(((2R)-2-AMINO-2-(4-HYDROXYPHENYL)ACETYL)AMINO)-8-OXO-3-(1Z)-1-PROPEN-1-YL-, HYDRATE (1:1), (6R,7R)-;5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7-((AMINO(4-HYDROXYPHENYL)ACETYL)AMINO)-8-OXO-3-(1-PROPENYL)-, MONOHYDRATE, (6R-(3(Z),6.ALPHA.,7.BETA.(R*)))-

Chemical Property of Cefprozil, (Z)-

Chemical Property:

• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 407.11510657
• Heavy Atom Count: 28
• Complexity: 699

Purity/Quality:

99%, ^*data from raw suppliers

Cefprozil (Z)-Isomer ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC=CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O.O
• Isomeric SMILES: C/C=C\C1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)SC1)C(=O)O.O

Technology Process of Cefprozil, (Z)-

There total 3 articles about Cefprozil, (Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate (886219-90-5) → cefprozil (114876-72-1,121123-17-9) + (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid monohydrate (111900-24-4,114876-72-1,121123-17-9)

Guidance literature:

In water; for 1h;

Reference yield:

(6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate (886219-90-5) → cefprozil (114876-72-1,121123-17-9) + (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid monohydrate (111900-24-4,114876-72-1,121123-17-9)

Guidance literature:

In water; for 1h;

Reference yield:

7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid DMF solvate → 7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid monohydrate (114876-72-1,121123-17-9)

Guidance literature:

With water; In ethyl acetate; for 1h; Product distribution / selectivity;

upstream raw materials:

(6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate