4-benzyloxymethyl-7c-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione

Base Information

Chemical Name:4-benzyloxymethyl-7c-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione
CAS No.:61378-01-6
Molecular Formula:C₂₈H₂₈N₂O₅S₂
Molecular Weight:536.673
Hs Code.:

4-benzyloxymethyl-7<i>c</i>-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6a<i>c</i>)-7,11-dihydro-6a<i>H</i>-4<i>r</i>,11a<i>c</i>-azaethano-[1,3,5]dithiazepino[5,4-<i>a</i>]indole-5,12-dione

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Chemical Property of 4-benzyloxymethyl-7c-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione

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Technology Process of 4-benzyloxymethyl-7c-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione

There total 27 articles about 4-benzyloxymethyl-7c-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.3%

: 3587-60-8
Benzyloxymethyl chloride

: 61378-00-5,79355-35-4,79355-36-5
(1R,3R,5R)-6-((1S,6S)-2-Chloromethyl-6-hydroxy-cyclohexa-2,4-dienyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

: 61378-01-6,79298-64-9,79298-72-9
C₂₈H₂₈N₂O₅S₂

Guidance literature:: With phenyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h;
DOI:10.1016/S0040-4020(01)97960-8

Reference yield: 47.5%

: 3587-60-8
Benzyloxymethyl chloride

: 61378-00-5,79355-35-4,79355-36-5
(1R,3S,5R)-6-((1S,6S)-2-Chloromethyl-6-hydroxy-cyclohexa-2,4-dienyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

: 61378-01-6,79298-64-9,79298-72-9
C₂₈H₂₈N₂O₅S₂

Guidance literature:: With phenyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h;
DOI:10.1016/S0040-4020(01)97960-8

Reference yield:

: 79355-33-2,79355-34-3
(1RS)-6-((1SR)-6t-acetoxy-2-chloromethyl-cyclohexa-2,4-dien-r-yl)-3ξ-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

: 61378-01-6,79298-64-9,79298-72-9
4-benzyloxymethyl-7c-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione

Guidance literature:: Multi-step reaction with 2 steps

1: NaOMe / methanol; CH₂Cl₂

2: PhLi / tetrahydrofuran

With sodium methylate; phenyllithium; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00437a063