Technology Process of (2E)-3-(2-ethyl-7-fluoro-3,4-dihydro-4-oxo-3-phenethylquinazolin-6-yl)-N-hydroxyacrylamide
There total 6 articles about (2E)-3-(2-ethyl-7-fluoro-3,4-dihydro-4-oxo-3-phenethylquinazolin-6-yl)-N-hydroxyacrylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; potassium hydroxide;
In
methanol;
at 0 - 20 ℃;
for 5h;
- Guidance literature:
-
With
hydroxylamine hydrochloride; potassium hydroxide;
In
methanol;
at 0 ℃;
DOI:10.1021/jm400564j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium iodide; acetic acid; sodium periodate; sodium chloride / water / 8 h / 20 °C
2: triphenyl phosphite; pyridine / 0.25 h / Microwave irradiation; Reflux
3: 0.17 h / Microwave irradiation; Reflux
4: tri tert-butylphosphoniumtetrafluoroborate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); N-Methyldicyclohexylamine / N,N-dimethyl-formamide / 0.83 h / Inert atmosphere; Microwave irradiation
5: hydroxylamine hydrochloride; potassium hydroxide / methanol / 0 °C
With
pyridine; triphenyl phosphite; sodium periodate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); N-Methyldicyclohexylamine; hydroxylamine hydrochloride; acetic acid; potassium iodide; sodium chloride; potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate;
In
methanol; water; N,N-dimethyl-formamide;
4: |Heck Reaction;
DOI:10.1021/jm400564j
