2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one

Base Information

Chemical Name:2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one
CAS No.:154344-46-4
Molecular Formula:C₁₅H₁₄N₂OS
Molecular Weight:270.355
Hs Code.:

Synonyms:

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Chemical Property of 2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one

Chemical Property:

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Technology Process of 2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one

There total 20 articles about 2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154344-34-0
2-(3-phenylpropyl)isothiazolo<5,4-b>pyridine-3(2H)-thione

: 154344-46-4
2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one

Guidance literature:: With mercury(II) diacetate; acetic acid; In chloroform; at 20 ℃; for 0.5h;
DOI:10.1016/S0014-827X(00)00084-7

Reference yield:

: 65282-42-0
1,2-dithiolo<5,4-b>pyridin-3-one

: 154344-46-4
2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 36 steps

1: ethanol / Heating

2: I₂; NaHCO₃ / ethanol

3: Lawesson's reagent / toluene / 0.5 h / Heating

4: H₂S / ethanol / pH 7.4

5: I₂; NaHCO₃ / ethanol

6: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

7: H₂S / ethanol / pH 7.4

8: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

9: ethanol / Heating

10: I₂; NaHCO₃ / ethanol

11: Lawesson's reagent / toluene / 0.5 h / Heating

12: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

13: H₂S / ethanol / pH 7.4

14: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

15: ethanol / Heating

16: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

17: ethanol / Heating

18: I₂; NaHCO₃ / ethanol

19: Lawesson's reagent / toluene / 0.5 h / Heating

20: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

21: H₂S / ethanol / pH 7.4

22: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

23: ethanol / Heating

24: I₂; NaHCO₃ / ethanol

25: Lawesson's reagent / toluene / 0.5 h / Heating

26: H₂S / ethanol / pH 7.4

27: I₂; NaHCO₃ / ethanol

28: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

29: H₂S / ethanol / pH 7.4

30: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

31: ethanol / Heating

32: I₂; NaHCO₃ / ethanol

33: Lawesson's reagent / toluene / 0.5 h / Heating

34: H₂S / ethanol / pH 7.4

35: I₂; NaHCO₃ / ethanol

36: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

With Lawessons reagent; hydrogen sulfide; mercury(II) diacetate; iodine; sodium hydrogencarbonate; acetic acid; In ethanol; chloroform; toluene;
DOI:10.1016/S0014-827X(00)00084-7

Reference yield:

: 91859-66-4
2-benzylisothiazolo<5,4-b>pyridin-3(2H)-one

: 154344-46-4
2-(3-phenylpropyl)isothiazolo<5,4-b>pyridin-3(2H)-one

Guidance literature:: Multi-step reaction with 18 steps

1: Lawesson's reagent / toluene / 0.5 h / Heating

2: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

3: H₂S / ethanol / pH 7.4

4: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

5: ethanol / Heating

6: I₂; NaHCO₃ / ethanol

7: Lawesson's reagent / toluene / 0.5 h / Heating

8: H₂S / ethanol / pH 7.4

9: I₂; NaHCO₃ / ethanol

10: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

11: H₂S / ethanol / pH 7.4

12: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

13: ethanol / Heating

14: I₂; NaHCO₃ / ethanol

15: Lawesson's reagent / toluene / 0.5 h / Heating

16: H₂S / ethanol / pH 7.4

17: I₂; NaHCO₃ / ethanol

18: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

With Lawessons reagent; hydrogen sulfide; mercury(II) diacetate; iodine; sodium hydrogencarbonate; acetic acid; In ethanol; chloroform; toluene;
DOI:10.1016/S0014-827X(00)00084-7