3-[1-(4-methoxyphenyl)-1H-tetraazol-5-yl]-4-methylquinoline

Base Information

• Chemical Name: 3-[1-(4-methoxyphenyl)-1H-tetraazol-5-yl]-4-methylquinoline
• CAS No.: 161464-68-2
• Molecular Formula: C₁₈H₁₅N₅O
• Molecular Weight: 317.35
• Mol file: 161464-68-2.mol

Synonyms:

Chemical Property of 3-[1-(4-methoxyphenyl)-1H-tetraazol-5-yl]-4-methylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-(4-methoxyphenyl)-1H-tetraazol-5-yl]-4-methylquinoline

There total 3 articles about 3-[1-(4-methoxyphenyl)-1H-tetraazol-5-yl]-4-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(2-{(Z)-2-[1-(4-Methoxy-phenyl)-1H-tetrazol-5-yl]-vinylamino}-phenyl)-ethanone → 3-[1-(4-Methoxy-phenyl)-1H-tetrazol-5-yl]-4-methyl-quinoline (161464-68-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Heating;

DOI:10.1002/jhet.5570310642

Reference yield:

2-aminoacetophenone (551-93-9) → 3-[1-(4-Methoxy-phenyl)-1H-tetrazol-5-yl]-4-methyl-quinoline (161464-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / aq. HCl / methanol

2: 94 percent / EtONa / ethanol / 1 h / Heating

With hydrogenchloride; sodium ethanolate; In methanol; ethanol;

DOI:10.1002/jhet.5570310642

Reference yield:

(E)-5-(2-Dimethylamino-vinyl)-1-(4-methoxy-phenyl)-1H-tetrazol (125037-40-3) → 3-[1-(4-Methoxy-phenyl)-1H-tetrazol-5-yl]-4-methyl-quinoline (161464-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / aq. HCl / methanol

2: 94 percent / EtONa / ethanol / 1 h / Heating

With hydrogenchloride; sodium ethanolate; In methanol; ethanol;

DOI:10.1002/jhet.5570310642

upstream raw materials:

2-aminoacetophenone

(E)-5-(2-Dimethylamino-vinyl)-1-(4-methoxy-phenyl)-1H-tetrazol

Refernces