Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-3-acetoxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Base Information

• Chemical Name: Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-3-acetoxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
• CAS No.: 187219-48-3
• Molecular Formula: C₃₁H₄₂O₆
• Molecular Weight: 510.671
• Mol file: 187219-48-3.mol

Synonyms:

Chemical Property of Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-3-acetoxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-3-acetoxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

There total 1 articles about Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-3-acetoxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

acetic anhydride (108-24-7) + Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-hydroxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (174815-57-7) → Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-3-acetoxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (187219-48-3)

Guidance literature:

With pyridine; for 18h; Ambient temperature;

DOI:10.1135/cccc19961647

Reference yield:

Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-3-acetoxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (187219-48-3) → Benzoic acid (3S,8R,9S,10R,13S,14S,17S)-17-acetoxy-15-[(E)-methoxycarbonylmethoxyimino]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (187219-53-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 80 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, H₂O / CH₂Cl₂ / 0.33 h

2: 81 percent / Jones reagent / acetone / 0.08 h / Ambient temperature

3: pyridine / 18 h / Ambient temperature

4: diethyl ether; methanol

5: 33 percent / HCl/MeOH / 3 h / 18 °C

6: 71 percent / pyridine / 18 h / Ambient temperature

With pyridine; hydrogenchloride; methanol; jones reagent; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diethyl ether; dichloromethane; acetone;

DOI:10.1135/cccc19961647

Reference yield:

Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-3-acetoxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (187219-48-3) → Benzoic acid (3S,8R,9S,10R,13S,14S,17S)-17-hydroxy-15-[(E)-methoxycarbonylmethoxyimino]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (187219-54-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 80 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, H₂O / CH₂Cl₂ / 0.33 h

2: 81 percent / Jones reagent / acetone / 0.08 h / Ambient temperature

3: pyridine / 18 h / Ambient temperature

4: diethyl ether; methanol

5: 33 percent / HCl/MeOH / 3 h / 18 °C

6: 71 percent / pyridine / 18 h / Ambient temperature

7: 72 percent / HCl/MeOH / 18 h / 45 °C

With pyridine; hydrogenchloride; methanol; jones reagent; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diethyl ether; dichloromethane; acetone;

DOI:10.1135/cccc19961647

upstream raw materials:

acetic anhydride

Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-hydroxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Downstream raw materials:

Benzoic acid (3S,8R,9S,10R,13S,14S,17S)-17-hydroxy-15-[(E)-methoxycarbonylmethoxyimino]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Benzoic acid (3S,8R,9S,10R,13S,14S)-15-[(E)-methoxycarbonylmethoxyimino]-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Benzoic acid (3S,8R,9S,10R,13S,14S,17S)-17-acetoxy-15-[(E)-methoxycarbonylmethoxyimino]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester