Ethyl 1,7-naphthyridine-2-carboxylate

Base Information

Chemical Name:Ethyl 1,7-naphthyridine-2-carboxylate
CAS No.:250674-53-4
Molecular Formula:C₁₁H₁₀N₂O₂
Molecular Weight:202.213
Hs Code.:
DSSTox Substance ID:DTXSID70699667
Wikidata:Q82630673
Mol file:250674-53-4.mol

Synonyms:Ethyl 1,7-naphthyridine-2-carboxylate;250674-53-4;DTXSID70699667;Ethyl1,7-naphthyridine-2-carboxylate;CS-0450119;EN300-256103;A924470

Suppliers and Price of Ethyl 1,7-naphthyridine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ethyl1,7-naphthyridine-2-carboxylate
2.5mg
$ 45.00

Matrix Scientific
Ethyl 1,7-naphthyridine-2-carboxylate 97%
1g
$ 2632.00

Crysdot
Ethyl1,7-naphthyridine-2-carboxylate 95+%
1g
$ 1307.00

Atlantic Research Chemicals
Ethyl1,7-Naphthyridine-2-carboxylate 95%
1gm:
$ 1127.53

Alichem
Ethyl1,7-naphthyridine-2-carboxylate
1g
$ 1142.64

Total 3 raw suppliers

Chemical Property of Ethyl 1,7-naphthyridine-2-carboxylate

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:202.074227566
Heavy Atom Count:15
Complexity:233

Purity/Quality:

97% ^*data from raw suppliers

ethyl1,7-naphthyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=NC2=C(C=C1)C=CN=C2

Technology Process of Ethyl 1,7-naphthyridine-2-carboxylate

There total 2 articles about Ethyl 1,7-naphthyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4,8-dichloro-[1,7]naphthyridine-2-carboxylic acid ethyl ester

: 250674-53-4
[1,7]naphthyridine-2-carboxylic acid ethyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate; In dimethyl sulfoxide; at 100 ℃;
DOI:10.1016/S0960-894X(99)00435-7

Reference yield:

: 8-chloro-4-oxo-1,4-dihydro-[1,7]naphthyridine-2-carboxylic acid ethyl ester

: 250674-53-4
[1,7]naphthyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / SOCl₂

2: Pd(PPh₃)4; sodium formate / dimethylsulfoxide / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium formate; In dimethyl sulfoxide; 1: Chlorination / 2: Reduction;
DOI:10.1016/S0960-894X(99)00435-7

Reference yield:

: 250674-53-4
[1,7]naphthyridine-2-carboxylic acid ethyl ester

: [1,7]naphthyridine-2-carboxylic acid 2-methoxy-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: aq. LiOH / tetrahydrofuran

2: EDCI; HOBt / dimethylformamide

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Acylation;
DOI:10.1016/S0960-894X(99)00435-7