1,7-Naphthyridine-2-carboxylic acid

Base Information

Chemical Name:1,7-Naphthyridine-2-carboxylic acid
CAS No.:316155-87-0
Molecular Formula:C₉H₆N₂O₂
Molecular Weight:174.159
Hs Code.:2933990090
European Community (EC) Number:847-408-2
DSSTox Substance ID:DTXSID40573086
Nikkaji Number:J1.413.119A
Wikidata:Q82461672
Mol file:316155-87-0.mol

Synonyms:1,7-NAPHTHYRIDINE-2-CARBOXYLIC ACID;316155-87-0;1,7-NAPHTHYRIDINE-2-CARBOXYLICACID;SCHEMBL2881764;DTXSID40573086;MFCD11521579;AKOS006322864;AB64278;PS-18136;CS-0450933;EN300-105071;Z1198330967

Suppliers and Price of 1,7-Naphthyridine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,7-Naphthyridine-2-carboxylicAcid
25mg
$ 285.00

Crysdot
1,7-Naphthyridine-2-carboxylicacid 95+%
1g
$ 950.00

Crysdot
1,7-Naphthyridine-2-carboxylicacid 95+%
100mg
$ 238.00

Crysdot
1,7-Naphthyridine-2-carboxylicacid 95+%
250mg
$ 380.00

American Custom Chemicals Corporation
1,7-NAPHTHYRIDINE-2-CARBOXYLIC ACID 95.00%
5MG
$ 500.10

Alichem
1,7-Naphthyridine-2-carboxylicacid
1g
$ 950.40

AK Scientific
1,7-Naphthyridine-2-carboxylicacid
10g
$ 5085.00

AK Scientific
1,7-Naphthyridine-2-carboxylicacid
5g
$ 3470.00

AK Scientific
1,7-Naphthyridine-2-carboxylicacid
100mg
$ 530.00

AccelPharmtech
1,7-Naphthyridine-2-carboxylicacid 97.00%
25G
$ 5120.00

Total 11 raw suppliers

Chemical Property of 1,7-Naphthyridine-2-carboxylic acid

Chemical Property:

Boiling Point:385.8±27.0 °C(Predicted)
PKA:3.99±0.30(Predicted)
PSA：63.08000
Density:1.421±0.06 g/cm3(Predicted)
LogP:1.32800
Storage Temp.:2-8°C
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:174.042927438
Heavy Atom Count:13
Complexity:208

Purity/Quality:

97% ^*data from raw suppliers

1,7-Naphthyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC2=C1C=CN=C2)C(=O)O

Technology Process of 1,7-Naphthyridine-2-carboxylic acid

There total 5 articles about 1,7-Naphthyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 250674-53-4
[1,7]naphthyridine-2-carboxylic acid ethyl ester

: 316155-87-0
2-carboxy-(1,6)-naphthyridine

Guidance literature:: With lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00435-7

Reference yield:

: 116026-95-0
3--4-pyridinecarboxaldehyde

: 316155-87-0
2-carboxy-(1,6)-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: NaOH / H₂O

With sodium hydroxide; trifluoroacetic acid; In dichloromethane; water; 1: Decarboxylation / 2: Condensation;
DOI:10.1016/S0040-4039(00)01400-3

Reference yield:

: 8-chloro-4-oxo-1,4-dihydro-[1,7]naphthyridine-2-carboxylic acid ethyl ester

: 316155-87-0
2-carboxy-(1,6)-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / SOCl₂

2: Pd(PPh₃)4; sodium formate / dimethylsulfoxide / 100 °C

3: aq. LiOH / tetrahydrofuran

With lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium formate; In tetrahydrofuran; dimethyl sulfoxide; 1: Chlorination / 2: Reduction / 3: Hydrolysis;
DOI:10.1016/S0960-894X(99)00435-7