Technology Process of 3H-Pyrazol-3-one, 5-ethyl-1,2-dihydro-1,2-dimethyl-4-phenyl-
There total 3 articles about 3H-Pyrazol-3-one, 5-ethyl-1,2-dihydro-1,2-dimethyl-4-phenyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; phenyllithium;
In
tetrahydrofuran; diethyl ether;
1.) -78 deg C, 30 min, 2.) reflux, 1 h;
DOI:10.1007/BF00476205
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 70 percent / Na2CO3 / H2O / 5 - 10 °C
2: 65 percent / 40percent NaOH / H2O / 0.5 h / 90 °C
3: 94 percent / LiN(SiMe3)2, TMEDA / tetrahydrofuran / 1) -78 deg C, 30 min, 2) RT, 3) 60 min, reflux
With
sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; water;
DOI:10.1055/s-1991-26588
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 70 percent / sodium carbonate / H2O / 0.5 h
2: 65 percent / 40percent aq. NaOH / 0.5 h / 90 °C
3: 94 percent / hexamethylphosphoric triamide, phenyllithium / tetrahydrofuran; diethyl ether / 1.) -78 deg C, 30 min, 2.) reflux, 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; sodium carbonate; phenyllithium;
In
tetrahydrofuran; diethyl ether; water;
DOI:10.1007/BF00476205
