Isocostic acid

Base Information

• Chemical Name: Isocostic acid
• CAS No.: 62458-44-0
• Molecular Formula: C₁₅H₂₂O₂
• Molecular Weight: 234.338
• Mol file: 62458-44-0.mol

Synonyms:2-Naphthaleneaceticacid, 1,2,3,4,4a,5,6,7-octahydro-4a,8-dimethyl-a-methylene-, (2R-cis)-; Eudesma-4,11(13)-dien-12-oicacid; Isocostic acid; g-Costic acid

Chemical Property of Isocostic acid

Chemical Property:

• PSA: 37.30000
• LogP: 3.93400

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isocostic acid

There total 9 articles about Isocostic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(7,7-ethylenedithio-cis-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphthtalen-2-yl)-propenoic acid → (+/-)-iscostic acid (62458-44-0)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; diethylene glycol; at 90 - 115 ℃; for 3.25h;

Reference yield: 55.0%

4-hydroxy-11(13)-eudesmen-12-oic acid (4586-68-9) → 2-((2R,4aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalen-2-yl)acrylic acid (69978-82-1,62458-44-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; at 80 ℃; Molecular sieve;

DOI:10.1016/j.bmc.2009.07.053

Reference yield:

germacra-1(10),4,11(13)-trien-12-oic acid (347377-92-8) → β-costic acid (3650-43-9) + 2-((2R,4aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalen-2-yl)acrylic acid (69978-82-1,62458-44-0) + (+)-Eudesma-3,11(13)-dien-12-oic acid (28399-17-9)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.116667h;

DOI:10.1016/S0031-9422(01)00291-6

upstream raw materials:

ilicic acid

4-hydroxy-11⁽¹³⁾-eudesmen-12-oic acid

germacra-1⁽¹⁰⁾,4,11⁽¹³⁾-trien-12-oic acid

1,4a-dimethyl-4,4a,5,6,-tetrahydronaphthalen-2(3H)-one