(R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one

Base Information

Chemical Name:(R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one
CAS No.:74231-33-7
Molecular Formula:C₂₈H₃₈O₄Si
Molecular Weight:466.693
Hs Code.:

Synonyms:

Suppliers and Price of (R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one

There total 15 articles about (R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74231-32-6
(R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-2,4-dimethyl-pentyl]-3-methyl-dihydro-furan-2-one

: 74231-33-7
(R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one

Guidance literature:: With sodium acetate; pyridinium chlorochromate; In dichloromethane;
DOI:10.1021/jo01305a044

Reference yield:

: 74231-27-9
(2R,4R,5R)-2,4-Dimethyl-hept-6-ene-1,5-diol

: 74231-33-7
(R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1) Et₃N, DMAP / 1)CH₂Cl₂

2: 1)LDA / 1) THF, 2) HMPA

3: Claisen rearrangement

4: KOH

5: 1) OsO₄, 2) camphorsulfonic acid / 1) pyridine, 2) benzene

6: PCC, NaOAc / CH₂Cl₂

With dmap; potassium hydroxide; osmium(VIII) oxide; camphor-10-sulfonic acid; sodium acetate; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo01305a044

Reference yield:

: 74231-22-4
(3aR,4R,6aS)-4-Methyl-3,3a,4,6a-tetrahydro-cyclopenta[b]furan-2-one

: 74231-33-7
(R)-5-[(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoyl]-3-methyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 11 steps

2: 81 percent / LDA / tetrahydrofuran

3: 84 percent / 10percent HCl / tetrahydrofuran

4: 1) o-NO₂C₆H₄SeCN, Bu₃P, 2) 50percent H₂O₂ / 1)THF

5: 94 percent / LiAlH₄

6: 1) Et₃N, DMAP / 1)CH₂Cl₂

7: 1)LDA / 1) THF, 2) HMPA

8: Claisen rearrangement

9: KOH

10: 1) OsO₄, 2) camphorsulfonic acid / 1) pyridine, 2) benzene

11: PCC, NaOAc / CH₂Cl₂

With hydrogenchloride; dmap; potassium hydroxide; osmium(VIII) oxide; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; tributylphosphine; camphor-10-sulfonic acid; dihydrogen peroxide; sodium acetate; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo01305a044