{(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester
• CAS No.: 98376-32-0
• Molecular Formula: C₄₆H₄₂FN₄O₁₀P
• Molecular Weight: 860.832

Synonyms:

Chemical Property of {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

There total 3 articles about {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-Oxo-propyl)-carbamic acid 4-nitro-benzyl ester (98376-30-8) → {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (98376-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / from 60 to 80 degC

DOI:10.1016/S0040-4039(00)94906-2

Reference yield:

4-nitrobenzyl chloroformate (4457-32-3) → {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (98376-32-0)

Guidance literature:

Multi-step reaction with 3 steps

2: 93 percent / from 60 to 80 degC

DOI:10.1016/S0040-4039(00)94906-2

Reference yield:

p-nitrobenzyl glyoxylate monohydrate (83654-96-0) + {(E)-6-[(2S,3S)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-5-oxo-hex-3-enyl}-carbamic acid 4-nitro-benzyl ester (98376-31-9) + triphenylphosphine (603-35-0) → {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (98376-32-0)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(00)94906-2

upstream raw materials:

p-nitrobenzyl glyoxylate monohydrate

{(E)-6-[(2S,3S)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-5-oxo-hex-3-enyl}-carbamic acid 4-nitro-benzyl ester

triphenylphosphine

(3-Oxo-propyl)-carbamic acid 4-nitro-benzyl ester

Downstream raw materials:

(5R,6R)-6-(1-Fluoro-ethyl)-3-[(E)-4-(4-nitro-benzyloxycarbonylamino)-but-1-enyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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