98376-30-8

Upstream product

• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 98376-31-9 {(E)-6-[(2S,3S)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-5-oxo-hex-3-enyl}-carbamic acid 4-nitro-benzyl ester 
• 98376-38-6 {(E)-(R)-6-[(2R,3R)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-5-oxo-hept-3-enyl}-carbamic acid 4-nitro-benzyl ester 
• 98376-38-6 {(E)-(S)-6-[(2R,3R)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-5-oxo-hept-3-enyl}-carbamic acid 4-nitro-benzyl ester 
• 98376-39-7 {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-(R)-1-methyl-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 98376-39-7 {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-(S)-1-methyl-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 98376-40-0 (4S,5R,6R)-6-(1-Fluoro-ethyl)-4-methyl-3-[(E)-4-(4-nitro-benzyloxycarbonylamino)-but-1-enyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 98376-40-0 (4R,5R,6R)-6-(1-Fluoro-ethyl)-4-methyl-3-[(E)-4-(4-nitro-benzyloxycarbonylamino)-but-1-enyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 98376-32-0 {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 98376-33-1 (5R,6R)-6-(1-Fluoro-ethyl)-3-[(E)-4-(4-nitro-benzyloxycarbonylamino)-but-1-enyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF 3-AMINOALKYL SUBSTITUTED CARBAPENEMS VIA A PHOSPHORANE INTERMEDIATE

Reaction of azetidinone phosphoranes 1 with aldehyde 8 gave the olefins 4, which were converted into carbapenem esters 6 in 4 steps.Hydrogenation of 6 gave the title compounds.