Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

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Chemical Name:Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine
CAS No.:86365-08-4
Molecular Formula:C₆H₁₅N*C₄₃H₃₉N₂O₁₀PS₃
Molecular Weight:972.154
Hs Code.:

Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

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Chemical Property of Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

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Technology Process of Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

There total 5 articles about Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 86365-08-4
Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 9 h / Ambient temperature

2: mesitylene-1,3-disulfonyl chloride / pyridine

3: phosphinic acid / pyridine; triethylamine / 0.25 h / Ambient temperature

With mesitylene-1,3-disulfonyl chloride; hypophosphorous acid; In pyridine; triethylamine;
DOI:10.1021/jo00166a039

Reference yield:

: 86365-03-9
2'-O-(1,3-benzothiol-2-yl)uridine

: 86365-08-4
Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 9 h / Ambient temperature

2: mesitylene-1,3-disulfonyl chloride / pyridine

3: phosphinic acid / pyridine; triethylamine / 0.25 h / Ambient temperature

With mesitylene-1,3-disulfonyl chloride; hypophosphorous acid; In pyridine; triethylamine;
DOI:10.1021/jo00166a039

Reference yield:

: 86365-02-8
2'-O-(1,3-benzodithiol-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 86365-08-4
Thiophosphoric acid O-[(2R,3R,4R,5R)-4-(benzo[1,3]dithiol-2-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / potassium fluoride, tetraethylammonium bromide / acetonitrile; H₂O / 1 h / 60 °C

2: pyridine / 9 h / Ambient temperature

3: mesitylene-1,3-disulfonyl chloride / pyridine

4: phosphinic acid / pyridine; triethylamine / 0.25 h / Ambient temperature

With potassium fluoride; mesitylene-1,3-disulfonyl chloride; tetraethylammonium bromide; hypophosphorous acid; In pyridine; water; triethylamine; acetonitrile;
DOI:10.1021/jo00166a039