4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine

Base Information

• Chemical Name: 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine
• CAS No.: 357624-03-4
• Molecular Formula: C₅₄H₇₁N₁₁O₁₅P₂Si₂
• Molecular Weight: 1232.34

Synonyms:

Chemical Property of 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine

There total 8 articles about 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C54H71N11O14P2Si2 → 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine (357624-03-4)

Guidance literature:

With pyridine; water; iodine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1081/NCN-100002081

Reference yield:

4-N-benzoyl-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine (357624-01-2) → 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine (357624-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / CH₂Cl₂ / 3.5 h / 20 °C

2: 650 mg / I₂; pyridine; H₂O / CH₂Cl₂; tetrahydrofuran / 0.17 h / 20 °C

With pyridine; 1H-tetrazole; water; iodine; In tetrahydrofuran; dichloromethane;

DOI:10.1081/NCN-100002081

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-OP-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine (357624-03-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 1H-tetrazole / CH₂Cl₂ / 2 h / 20 °C

2: 1H-tetrazole / CH₂Cl₂ / 3 h / 20 °C

3: I₂; pyridine; H₂O / CH₂Cl₂; tetrahydrofuran / 0.17 h / 20 °C

4: 515 mg / TFA / CH₂Cl₂ / 0.08 h / 20 °C

5: 1H-tetrazole / CH₂Cl₂ / 3.5 h / 20 °C

6: 650 mg / I₂; pyridine; H₂O / CH₂Cl₂; tetrahydrofuran / 0.17 h / 20 °C

With pyridine; 1H-tetrazole; water; iodine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1081/NCN-100002081

upstream raw materials:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

N₄-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3-O-[O-(2-cyanoethyl)-N,N-(diisopropyl)]phosphoramidite

4-N-benzoyl-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine

N⁶-benzoyl-2',3'-bis-O-<(1,1-dimethylethyl)dimethylsilyl>adenosine

Downstream raw materials:

5'-O-phosphoryl-2'-deoxycytidylyl-(3'->5')adenosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 357624-03-4 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send