2-(2,2-dichloroacetamido)ethyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Base Information

• Chemical Name: 2-(2,2-dichloroacetamido)ethyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate
• CAS No.: 1066865-61-9
• Molecular Formula: C₂₇H₃₇Cl₂N₃O₇S
• Molecular Weight: 618.579
• Mol file: 1066865-61-9.mol

Synonyms:

Chemical Property of 2-(2,2-dichloroacetamido)ethyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,2-dichloroacetamido)ethyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate

There total 4 articles about 2-(2,2-dichloroacetamido)ethyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H32N2O4S (1026701-89-2) + 2-(2,2-dichloroacetamido)ethyl (4-nitrophenyl)carbonate (1386394-46-2) → 2-(2,2-dichloroacetamido)ethyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate (1066865-61-9)

Guidance literature:

C₂₂H₃₂N₂O₄S; With tertiary amine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

2-(2,2-dichloroacetamido)ethyl (4-nitrophenyl)carbonate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm300238h

Reference yield:

N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester (1026701-52-9) → 2-(2,2-dichloroacetamido)ethyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate (1066865-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: tertiary amine / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0 - 20 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm300238h

Reference yield:

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2) → 2-(2,2-dichloroacetamido)ethyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-((S)-2-methylbutyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate (1066865-61-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethanol

2.1: sodium carbonate / dichloromethane; water / 6 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: tertiary amine / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0 - 20 °C

With sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/jm300238h

upstream raw materials:

N-[(1S,2R)-2-hydroxy-3-[((2S)-2-methylbutyl)amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester

N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]-1-(phenylmethyl)propyl]-carbamic acid 1,1-dimethylethyl ester

C₂₂H₃₂N₂O₄S

2-(2,2-dichloroacetamido)ethyl (4-nitrophenyl)carbonate