N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Base Information

Chemical Name:N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide
CAS No.:1027344-95-1
Molecular Formula:C₄₆H₄₇ClF₃N₇O₅S₃
Molecular Weight:966.569
Hs Code.:

N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

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Chemical Property of N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

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Technology Process of N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

There total 13 articles about N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027345-24-9
4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

: 1027345-12-5
[4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide

: 1027344-95-1
N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; at 150 ℃; for 0.75h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm101596e

Reference yield:

: 1027345-15-8
tert-butyl 4-(4-cyano-3-nitrophenyl)piperazine-1-carboxylate

: 1027344-95-1
N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetonitrile / 2 h / Inert atmosphere

2.1: triethylamine / isopropyl alcohol / 3 h / Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

5.1: ethyl methyl ether / 3 h / 120 °C / Inert atmosphere

6.1: hydrogenchloride; water; acetic acid / 9 h / 130 °C

7.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 21.25 h / 70 °C / Inert atmosphere

8.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 0.75 h / 150 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iron; sodium carbonate; caesium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; ethyl methyl ether; water; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1021/jm101596e

Reference yield:

: 2-nitro-4-(piperazin-1-yl)benzonitrile bistosylate

: 1027344-95-1
N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-(morpholin-4-yl)-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-(trifluoromethanesulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / isopropyl alcohol / 3 h / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

4.1: ethyl methyl ether / 3 h / 120 °C / Inert atmosphere

5.1: hydrogenchloride; water; acetic acid / 9 h / 130 °C

6.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 21.25 h / 70 °C / Inert atmosphere

7.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 0.75 h / 150 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iron; sodium carbonate; caesium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; ethyl methyl ether; water; 1,2-dichloro-ethane; isopropyl alcohol; 2.1: Suzuki coupling;
DOI:10.1021/jm101596e