2,3-Dihydro-6,7-dimethoxy-2-methyl-1H-inden-1-one

Base Information

Chemical Name:2,3-Dihydro-6,7-dimethoxy-2-methyl-1H-inden-1-one
CAS No.:138261-11-7
Molecular Formula:C12H14O3
Molecular Weight:
Hs Code.:
ChEMBL ID:CHEMBL350916
DSSTox Substance ID:DTXSID001232642
Nikkaji Number:J460.215C
Pharos Ligand ID:RMZC67ZPVA8B
Mol file:138261-11-7.mol

Synonyms:CHEMBL350916;2,3-Dihydro-6,7-dimethoxy-2-methyl-1H-inden-1-one;138261-11-7;DTXSID001232642;BDBM50008540;6,7-Dimethoxy-2-methyl-indan-1-one

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Chemical Property of 2,3-Dihydro-6,7-dimethoxy-2-methyl-1H-inden-1-one

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:206.094294304
Heavy Atom Count:15
Complexity:251

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CC2=C(C1=O)C(=C(C=C2)OC)OC

Technology Process of 2,3-Dihydro-6,7-dimethoxy-2-methyl-1H-inden-1-one

There total 3 articles about 2,3-Dihydro-6,7-dimethoxy-2-methyl-1H-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848610-65-1
5-(3,4-dimethoxybenzyl)-2,2,5-trimethyl-1,3-dioxane-4,6-dione

: 4191-17-7
5,6-dimethoxy-2- methyl-2,3-dihydro-1H-inden-1-one

: 138261-11-7
6,7-dimethoxy-2-methyl-1-indanone

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; Solvent; Schlenk technique; Reflux; Inert atmosphere;
DOI:10.15227/orgsyn.089.0115

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 4191-17-7
5,6-dimethoxy-2- methyl-2,3-dihydro-1H-inden-1-one

: 138261-11-7
6,7-dimethoxy-2-methyl-1-indanone

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine; acetic acid / ethanol / 0.5 h / 20 °C / Schlenk technique; Inert atmosphere

2: sodium tris(acetoxy)borohydride / ethanol / 3 h / 20 °C / Schlenk technique; Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / Schlenk technique; Inert atmosphere

4: trimethylsilyl trifluoromethanesulfonate / acetonitrile / Schlenk technique; Reflux; Inert atmosphere

With piperidine; trimethylsilyl trifluoromethanesulfonate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide; acetonitrile; 4: |Friedel-Crafts Acylation;
DOI:10.15227/orgsyn.089.0115

Reference yield:

: 67101-91-1
5-[(3,4-dimethoxyphenyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione

: 4191-17-7
5,6-dimethoxy-2- methyl-2,3-dihydro-1H-inden-1-one

: 138261-11-7
6,7-dimethoxy-2-methyl-1-indanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 20 °C / Schlenk technique; Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / Schlenk technique; Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / acetonitrile / Schlenk technique; Reflux; Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; sodium tris(acetoxy)borohydride; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetonitrile; 3: |Friedel-Crafts Acylation;
DOI:10.15227/orgsyn.089.0115