5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one

Base Information

Chemical Name:5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one
CAS No.:4191-17-7
Molecular Formula:C12H14O3
Molecular Weight:206.241
Hs Code.:2914509090
DSSTox Substance ID:DTXSID40446822
Nikkaji Number:J460.204H
Pharos Ligand ID:3UKPDLQ3CP8W
ChEMBL ID:CHEMBL154848
Mol file:4191-17-7.mol

Synonyms:4191-17-7;5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one;5,6-Dimethoxy-2-methyl-indan-1-one;5,6-dimethoxy-2-methyl-2,3-dihydroinden-1-one;CHEMBL154848;5,6-DIMETHOXY-2-METHYLINDAN-1-ONE;SCHEMBL8938844;2-methyl-5,6-dimethoxyindanone;DTXSID40446822;AC-353;BDBM50008565;AKOS015899903;N14243;A872978;2,3-Dihydro-5,6-dimethoxy-2-methyl-1H-inden-1-one

Suppliers and Price of 5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one 95+%
1g
$ 535.00

Biosynth Carbosynth
5,6-Dimethoxy-2-methyl-indan-1-one
1 g
$ 634.00

Biosynth Carbosynth
5,6-Dimethoxy-2-methyl-indan-1-one
250 mg
$ 210.00

Biosynth Carbosynth
5,6-Dimethoxy-2-methyl-indan-1-one
100 mg
$ 105.00

Biosynth Carbosynth
5,6-Dimethoxy-2-methyl-indan-1-one
50 mg
$ 60.00

Biosynth Carbosynth
5,6-Dimethoxy-2-methyl-indan-1-one
500 mg
$ 365.00

American Custom Chemicals Corporation
5,6-DIMETHOXY-2-METHYL-INDAN-1-ONE 95.00%
5G
$ 4365.90

American Custom Chemicals Corporation
5,6-DIMETHOXY-2-METHYL-INDAN-1-ONE 95.00%
1G
$ 1124.55

Alichem
5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one
1g
$ 440.36

Alichem
5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one
250mg
$ 233.28

Total 19 raw suppliers

Chemical Property of 5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one

Chemical Property:

Vapor Pressure:7.47E-05mmHg at 25°C
Melting Point:129-130 °C
Refractive Index:1.53
Boiling Point:342.5 °C at 760 mmHg
Flash Point:152.1 °C
PSA：35.53000
Density:1.126 g/cm³
LogP:2.07870
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:206.094294304
Heavy Atom Count:15
Complexity:251

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2=CC(=C(C=C2C1=O)OC)OC
Uses 5,6-Dimethoxy-2-methyl-indan-1-one is a useful reagent in the preparation of the phase III drug-?candidate, E2020, developed for treatment of Alzheimer''s and dementias.

Technology Process of 5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one

There total 24 articles about 5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 848610-65-1
5-(3,4-dimethoxybenzyl)-2,2,5-trimethyl-1,3-dioxane-4,6-dione

: 4191-17-7
5,6-dimethoxy-2- methyl-2,3-dihydro-1H-inden-1-one

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In nitromethane; at 100 ℃; for 0.75h;
DOI:10.1021/jo0483724

Reference yield: 76.0%

: methyl 2-allyl-4,5-dimethoxybenzoate

: 4191-17-7
5,6-dimethoxy-2- methyl-2,3-dihydro-1H-inden-1-one

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate; 1-Phenylethanol; potassium tert-butylate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In toluene; at 100 ℃; for 16h; Inert atmosphere; Sealed tube;
DOI:10.1002/anie.201911372

Reference yield: 72.0%

: 67-56-1
methanol

: 2107-69-9
5,6-dimethoxy-1-indanone

: 4191-17-7
5,6-dimethoxy-2- methyl-2,3-dihydro-1H-inden-1-one

Guidance literature:: With C₅₀H₃₂F₁₂N₄O₄Pd₂; lithium tert-butoxide; tricyclohexylphosphine; at 120 ℃; for 48h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.joc.9b00983