[2-(Pyridin-2-yl)-1h-indol-3-yl]acetic acid

Base Information

Chemical Name:[2-(Pyridin-2-yl)-1h-indol-3-yl]acetic acid
CAS No.:92437-52-0
Molecular Formula:C₁₅H₁₂N₂O₂
Molecular Weight:252.272
Hs Code.:
NSC Number:125867
DSSTox Substance ID:DTXSID70919170
Wikidata:Q82891636

Synonyms:92437-52-0;[2-(pyridin-2-yl)-1h-indol-3-yl]acetic acid;NSC125867;DTXSID70919170;NSC-125867

Suppliers and Price of [2-(Pyridin-2-yl)-1h-indol-3-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of [2-(Pyridin-2-yl)-1h-indol-3-yl]acetic acid

Chemical Property:

Vapor Pressure:1.03E-12mmHg at 25°C
Boiling Point:545.1°C at 760 mmHg
Flash Point:283.5°C
Density:1.343g/cm³
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:252.089877630
Heavy Atom Count:19
Complexity:334

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=C(N2)C3=CC=CC=N3)CC(=O)O

Technology Process of [2-(Pyridin-2-yl)-1h-indol-3-yl]acetic acid

There total 6 articles about [2-(Pyridin-2-yl)-1h-indol-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: potassium cyanide

: 21190-99-8
3-(dimethylaminomethyl)-2-(2-pyridyl)indole

: 92437-52-0
2-(2-pyridyl)indole-3-acetic acid

Guidance literature:: potassium cyanide; 3-(dimethylaminomethyl)-2-(2-pyridyl)indole; In ethanol; water; for 48h; Reflux;

With potassium hydroxide; In ethanol; water; for 22h; Reflux;
DOI:10.1002/jhet.3130

Reference yield:

: 1122-62-9
2-acetylpyridine

: 92437-52-0
2-(2-pyridyl)indole-3-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 1.5 h / 50 °C

2.1: polyphosphoric acid / 130 °C

3.1: acetic acid; potassium hydroxide / water / 2.5 h / 0 °C

4.1: ethanol; water / 48 h / Reflux

4.2: 22 h / Reflux

With acetic acid; potassium hydroxide; In ethanol; water; 2.1: |Fischer Indole Synthesis;
DOI:10.1002/jhet.3130

Reference yield:

: 7734-05-6
2-acetylpyridine phenylhydrazone

: 92437-52-0
2-(2-pyridyl)indole-3-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: polyphosphoric acid / 130 °C

2.1: acetic acid; potassium hydroxide / water / 2.5 h / 0 °C

3.1: ethanol; water / 48 h / Reflux

3.2: 22 h / Reflux

With acetic acid; potassium hydroxide; In ethanol; water; 1.1: |Fischer Indole Synthesis;
DOI:10.1002/jhet.3130