(2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide

Base Information

Chemical Name:(2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide
CAS No.:191408-13-6
Molecular Formula:C₃₄H₅₀N₄O₆S
Molecular Weight:642.86
Hs Code.:

(2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide

Synonyms:

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Chemical Property of (2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide

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Technology Process of (2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide

There total 6 articles about (2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191406-74-3
(2R,3S)-3-(tert-butoxycarbonyl)-2-isobutylhex-5-enoic acid benzyl ester

: 191408-13-6
(2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 9-BBN, 2.) NaOAc, H₂O₂

2: H₂ / Pd/C

3: BOP

4: DIAD, Ph₃P / tetrahydrofuran

5: TFA

6: BOP, iPr₂NEt

With 9-borabicyclo[3.3.1]nonane dimer; di-isopropyl azodicarboxylate; hydrogen; dihydrogen peroxide; sodium acetate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00178-X

Reference yield:

: 191406-75-4
4-benzyl 1-tert-butyl (2S,3R)-2-(3-hydroxypropyl)-3-isobutylbutanedioate

: 191408-13-6
(2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C

2: BOP

3: DIAD, Ph₃P / tetrahydrofuran

4: TFA

5: BOP, iPr₂NEt

With di-isopropyl azodicarboxylate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00178-X

Reference yield:

: 229318-21-2
(2R,3S)-3-(tert-butoxycarbonyl)-6-hydroxy-2-isobutylhexanoic acid

: 191408-13-6
(2S,11S,12R)-12-Isobutyl-13-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-1,7-diaza-cyclotridecane-2,11-dicarboxylic acid 11-(benzyloxy-amide) 2-methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: BOP

2: DIAD, Ph₃P / tetrahydrofuran

3: TFA

4: BOP, iPr₂NEt

With di-isopropyl azodicarboxylate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00178-X