γ-ethyl-α-tert-butyl ester of N-carbobenzoxyglutamic acid

Base Information

• Chemical Name: γ-ethyl-α-tert-butyl ester of N-carbobenzoxyglutamic acid
• CAS No.: 125076-24-6
• Molecular Formula: C₁₉H₂₇NO₆
• Molecular Weight: 365.426
• Mol file: 125076-24-6.mol

Synonyms:

Chemical Property of γ-ethyl-α-tert-butyl ester of N-carbobenzoxyglutamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of γ-ethyl-α-tert-butyl ester of N-carbobenzoxyglutamic acid

There total 3 articles about γ-ethyl-α-tert-butyl ester of N-carbobenzoxyglutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

acetic acid tert-butyl ester (540-88-5) + 2-Benzyloxycarbonylamino-pentanedioic acid 5-ethyl ester (35726-62-6,1029401-62-4) → γ-ethyl-α-tert-butyl ester of N-carbobenzoxyglutamic acid (125076-24-6)

Guidance literature:

With perchloric acid; for 48h; Ambient temperature;

DOI:10.1021/jo00293a010

Reference yield:

2-Amino-pentanedioic acid 5-ethyl ester (1119-33-1) → γ-ethyl-α-tert-butyl ester of N-carbobenzoxyglutamic acid (125076-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / H₂O; ethyl acetate / Ambient temperature

2: 66 percent / 70percent HClO₄ / 48 h / Ambient temperature

With perchloric acid; sodium hydrogencarbonate; In water; ethyl acetate;

DOI:10.1021/jo00293a010

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → γ-ethyl-α-tert-butyl ester of N-carbobenzoxyglutamic acid (125076-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / H₂O; ethyl acetate / Ambient temperature

2: 66 percent / 70percent HClO₄ / 48 h / Ambient temperature

With perchloric acid; sodium hydrogencarbonate; In water; ethyl acetate;

DOI:10.1021/jo00293a010

upstream raw materials:

acetic acid tert-butyl ester

2-Benzyloxycarbonylamino-pentanedioic acid 5-ethyl ester

2-Amino-pentanedioic acid 5-ethyl ester

benzyl chloroformate