N-Cbz-L-glutamic acid 5-ethyl ester

Base Information

• Chemical Name: N-Cbz-L-glutamic acid 5-ethyl ester
• CAS No.: 35726-62-6
• Molecular Formula: C15H19 N O6
• Molecular Weight: 309.319
• Hs Code.: 2924299090
• Mol file: 35726-62-6.mol

Synonyms:N-Carbobenzoxy-L-glutamicacid g-ethyl ester

Chemical Property of N-Cbz-L-glutamic acid 5-ethyl ester

Chemical Property:

• Melting Point: 87-88 °C
• Boiling Point: 517.9±50.0 °C(Predicted)
• PKA: 3.81±0.10(Predicted)
• PSA: 101.93000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 2.10020
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(((Benzyloxy)carbonyl)amino)-5-ethoxy-5-oxopentanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Cbz-L-glutamic acid 5-ethyl ester

There total 10 articles about N-Cbz-L-glutamic acid 5-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(S)-2-benzyloxycarbonylaminopentanedioic acid 1-allyl ester 5-ethyl ester (1245613-20-0) → (S)-2-(benzyloxycarbonylamino)-5-ethoxy-5-oxopentanoic acid (35726-62-6,1029401-62-4)

Guidance literature:

With methanol; recombinant Bacillus subtilis esterase double mutant E₁₈₈W/M₁₉₃C; In hexane; at 37 ℃; for 0.333333h; pH=7.4; regioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1002/adsc.200900325

Reference yield: 69.0%

(S)-2-benzyloxycarbonylaminopentanedioic acid 5-ethyl ester 1-(2-methoxyethyl) ester (1245613-19-7) → (S)-2-(benzyloxycarbonylamino)-5-ethoxy-5-oxopentanoic acid (35726-62-6,1029401-62-4)

Guidance literature:

With methanol; recombinant Bacillus subtilis esterase double mutant E₁₈₈W/M₁₉₃C; In hexane; at 37 ℃; for 0.416667h; pH=7.4; regioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1002/adsc.200900325

Reference yield:

(S)-2-Amino-pentanedioic acid 5-ethyl ester (1119-33-1) + benzyl chloroformate (501-53-1,94274-21-2) → (S)-2-(benzyloxycarbonylamino)-5-ethoxy-5-oxopentanoic acid (35726-62-6,1029401-62-4)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate;

upstream raw materials:

(S)-2-Amino-pentanedioic acid 5-ethyl ester

benzyl chloroformate

L-glutamic acid

(S)-2-benzyloxycarbonylaminopentanedioic acid 5-ethyl ester 1-(2-methoxyethyl) ester

Downstream raw materials:

N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

Cbz-L-Gln

N-(O-ethyl-N-benzyloxycarbonyl-L-α-glutamyl)-L-glutamic acid-5-ethyl ester

Z-L-theanine