rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

Base Information

Chemical Name:rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide
CAS No.:672949-12-1
Molecular Formula:C₂₅H₂₅ClN₄O₃S
Molecular Weight:497.018
Hs Code.:

rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

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Chemical Property of rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

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Technology Process of rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

There total 5 articles about rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 672326-01-1
N-(4-chlorobenzyl)-2-(chloromethyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

: 562101-27-3
rac-2-(methylamino)-1-pyridin-3-ylethanol hydrobromide

: 672949-12-1,672949-14-3
rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 90 ℃; for 2h;

Reference yield:

: 292144-09-3
N-(4-chlorobenzyl)-2-(hydroxymethyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

: 672949-12-1,672949-14-3
rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonyl chloride; 2,4,6-collidine; DMAP / dimethylformamide

2: i-Pr₂EtN / dimethylformamide

With 2,4,6-trimethyl-pyridine; dmap; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.102

Reference yield:

: 292144-10-6
PNU-243672

: 672949-12-1,672949-14-3
rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-3-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / ethyl chloroformate / CHCl₃ / Heating

2: i-Pr₂EtN / dimethylformamide

With chloroformic acid ethyl ester; N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.102