N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester

Base Information

Chemical Name:N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester
CAS No.:88818-13-7
Molecular Formula:C₄₈H₄₈ClN₃O₁₀
Molecular Weight:862.376
Hs Code.:

N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester

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Chemical Property of N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester

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Technology Process of N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester

There total 4 articles about N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88818-12-6
O-benzyl-N-<(3S,6S)-2-benzyloxycarbonyl-6-carboxy-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-L-threonine benzyl ester

: 908093-98-1
diazodiphenylmethane

: 88853-75-2
(3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester

: 88818-13-7
N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester

Guidance literature:: In dichloromethane; chloroform; for 0.5h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1016/S0040-4020(01)88799-8

Reference yield:

: 88818-10-4
(3S*,6S*)-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>-perhydro-1,2-oxazine-3,6-dicarboxylic acid

: 88818-13-7
N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / acetonitrile / 0.5 h / 0 °C

2: 0 deg C, 1 h, 25 deg C, 10 min

3: CH₂Cl₂ / 0.17 h / 25 °C

With triethylamine; In dichloromethane; acetonitrile;
DOI:10.1039/c39830001049

Reference yield:

: 88818-12-6,88853-24-1
(3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 2-benzyl ester

: 908093-98-1
diazodiphenylmethane

: 88853-75-2
(3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester

: 88818-13-7
N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester

Guidance literature:: In dichloromethane; chloroform; for 0.5h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1016/S0040-4020(01)88799-8