2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate

Base Information

• Chemical Name: 2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate
• CAS No.: 140679-76-1
• Molecular Formula: C₅₅H₅₅N₅O₁₅S₃
• Molecular Weight: 1122.26

Synonyms:2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate

Chemical Property of 2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate

Chemical Property:

Purity/Quality:

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Technology Process of 2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate

There total 3 articles about 2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

methanesulfonyl chloride (124-63-0) + 2-N,5’-O-bis(4,4’-dimethoxytrityl)-gunaosine (132625-21-9) → 2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine (132625-22-0) + 2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate (140679-76-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 5 ℃; for 0.3h;

DOI:10.1039/P19920000469

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate (140679-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / pyridine / dimethylsulfoxide / 3.5 h / Ambient temperature

2: 22 percent / NEt₃ / CH₂Cl₂ / 0.3 h / 0 - 5 °C

With pyridine; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/P19920000469

Reference yield:

G (118-00-3) → 2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine 6-O-methanesulfonate (140679-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / pyridine / dimethylsulfoxide / 3.5 h / Ambient temperature

2: 22 percent / NEt₃ / CH₂Cl₂ / 0.3 h / 0 - 5 °C

With pyridine; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/P19920000469

upstream raw materials:

methanesulfonyl chloride

2-N,5’-O-bis(4,4’-dimethoxytrityl)-gunaosine

4,4'-dimethoxytrityl chloride

G

Downstream raw materials:

2N',5'-O-bis(4,4'-dimethoxytrityl)-2',3'-bis-O-methylsulfonylguanosine

2N,5'-O-bis(4,4'-dimethoxytrityl)-9-<3-deoxy-2-O-methylsulfonyl-β-D-threo-pentofuranosyl>guanine

9-{(2R,3R,5S)-3-Azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

9-{(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-1,9-dihydro-purin-6-one

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