[4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

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Chemical Name:[4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone
CAS No.:929049-08-1
Molecular Formula:C₃₇H₅₀F₂N₄O₁₀S₄
Molecular Weight:877.086
Hs Code.:

[4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

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Chemical Property of [4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

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Technology Process of [4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

There total 5 articles about [4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929049-03-6
(2S,4R)-1-(4-Benzyloxy-5-methoxy-2-nitro-benzoyl)-4-fluoro-pyrrolidine-2-carbaldehyde

: 929049-08-1
[4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / TMSCl / CHCl₃ / 24 h / 20 °C

2: 80 percent / EtSH*BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

3: K₂CO₃ / acetone / Heating

With chloro-trimethyl-silane; EtSH*BF₃OEt₂; potassium carbonate; In dichloromethane; chloroform; acetone;
DOI:10.1016/j.bmcl.2006.10.070

Reference yield:

: 929049-02-5
methyl-(2S,4R)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-fluoropyrrolidine-2-carboxylate

: 929049-08-1
[4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / DIBAL-H / CH₂Cl₂ / 0.75 h / -78 °C

2: 85 percent / TMSCl / CHCl₃ / 24 h / 20 °C

3: 80 percent / EtSH*BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

4: K₂CO₃ / acetone / Heating

With chloro-trimethyl-silane; EtSH*BF₃OEt₂; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; chloroform; acetone;
DOI:10.1016/j.bmcl.2006.10.070

Reference yield:

: methyl-(2S,4S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4-hydroxypyrrolidine-2-carboxylate

: 929049-08-1
[4-(3-{4-[(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propoxy)-5-methoxy-2-nitro-phenyl]-[(2S,4R)-2-(bis-ethylsulfanyl-methyl)-4-fluoro-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / DAST / CH₂Cl₂ / 12 h / -78 - 20 °C

2: 80 percent / DIBAL-H / CH₂Cl₂ / 0.75 h / -78 °C

3: 85 percent / TMSCl / CHCl₃ / 24 h / 20 °C

4: 80 percent / EtSH*BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

5: K₂CO₃ / acetone / Heating

With chloro-trimethyl-silane; EtSH*BF₃OEt₂; diisobutylaluminium hydride; potassium carbonate; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; chloroform; acetone;
DOI:10.1016/j.bmcl.2006.10.070