<3aS<1<1S^*,3(R^*),5R^*,6R^*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

Base Information

• Chemical Name: <3aS<1<1S^*,3(R^*),5R^*,6R^*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide
• CAS No.: 127381-65-1
• Molecular Formula: C₃₂H₄₇N₃O₆SSi
• Molecular Weight: 629.893
• Mol file: 127381-65-1.mol

Synonyms:

Chemical Property of <3aS<1<1S^*,3(R^*),5R^*,6R^*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <3aS<1<1S^*,3(R^*),5R^*,6R^*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

There total 3 articles about <3aS<1<1S^*,3(R^*),5R^*,6R^*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(S)-3-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-6-methyl-3,6-diazabicyclo<3.1.0>hexane-2,4-dione (127381-60-6) + acrylcamphorsultam (94594-91-9) → <3aS<1<1S*,3(R*),5R*,6R*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (127381-65-1)

Guidance literature:

In 1,4-dioxane; Irradiation; repeated portionwise addition of dipolarophile;

DOI:10.1021/jo00020a035

Reference yield:

(S)-1-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-1H-pyrrole-2,5-dione (120417-15-4) → <3aS<1<1S*,3(R*),5R*,6R*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (127381-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / toluene / 24 h / Ambient temperature

2: 93 percent / dioxane / 5 h / Irradiation

3: 45 percent / dioxane / Irradiation; repeated portionwise addition of dipolarophile

In 1,4-dioxane; toluene;

DOI:10.1021/jo00020a035

Reference yield:

5-<(S)-2-<<(1,1-Dimethylethyl)dimethylsilyll>oxy>-1-phenylethyl>-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione (120417-16-5,135557-52-7,135557-53-8) → <3aS<1<1S*,3(R*),5R*,6R*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (127381-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / dioxane / 5 h / Irradiation

2: 45 percent / dioxane / Irradiation; repeated portionwise addition of dipolarophile

In 1,4-dioxane;

DOI:10.1021/jo00020a035

upstream raw materials:

(S)-3-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-6-methyl-3,6-diazabicyclo<3.1.0>hexane-2,4-dione

acrylcamphorsultam

5-<(S)-2-<<(1,1-Dimethylethyl)dimethylsilyll>oxy>-1-phenylethyl>-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione

(S)-1-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-1H-pyrrole-2,5-dione

Downstream raw materials:

<1R<1α,3(S^*),5α,6α>>-3-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>octane-6-carboxylic acid ethyl ester

(2R)-bornane-10,2-sultam