2-Propen-1-one, 3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)-

Base Information

• Chemical Name: 2-Propen-1-one, 3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)-
• CAS No.: 138469-95-1
• Molecular Formula: C11H12FNO2
• Molecular Weight: 209.22
• Mol file: 138469-95-1.mol

Synonyms:2-Propen-1-one,3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl);1-(4-Fluor-2-hydroxyphenyl)-3-dimethylamino-2-propen-1-on;3-dimethylamino-1-(4-fluoro-2-hydroxyphenyl)propenone;

Chemical Property of 2-Propen-1-one, 3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)-

Chemical Property:

• Boiling Point: 325.6±42.0 °C(Predicted)
• PSA: 40.54000
• Density: 1.202±0.06 g/cm3(Predicted)
• LogP: 1.78930

Purity/Quality:

3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)prop-2-en-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propen-1-one, 3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)-

There total 3 articles about 2-Propen-1-one, 3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-Fluoro-2-hydroxyacetophenone (1481-27-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (E)-3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)prop-2-en-1-one (138469-95-1)

Guidance literature:

for 1h; Heating;

DOI:10.1002/ardp.2503241202

Reference yield: 76.0%

4-Fluoro-2-hydroxyacetophenone (1481-27-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 1-(4-Fluor-2-hydroxyphenyl)-3-dimethylamino-2-propen-1-on (138469-95-1)

Guidance literature:

for 1h; Heating;

DOI:10.1002/ardp.19943270413

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 1-(4-Fluor-2-hydroxyphenyl)-3-dimethylamino-2-propen-1-on (138469-95-1)

Guidance literature:

In para-xylene; Reflux;

DOI:10.1021/ja107758d

upstream raw materials:

4-Fluoro-2-hydroxyacetophenone

N,N-dimethyl-formamide dimethyl acetal

1-(4-fluorophenyl)ethanone

Downstream raw materials:

4-fluorosalicylic acid

(E)-3-(dimethylamino)-1-(4-fluoro-2-(pyridin-2-yloxy)phenyl)prop-2-en-1-one

(E)-3-(dimethylamino)-1-(4-fluoro-2-phenoxyphenyl)prop-2-en-1-one

(E)-1-(2-(4-chlorophenoxy)-4-fluorophenyl)-3-(dimethylamino)prop-2-en-1-one