(-)-brunsvigine

Base Information

• Chemical Name: (-)-brunsvigine
• CAS No.: 1071759-60-8
• Molecular Formula: C₁₆H₁₇NO₄
• Molecular Weight: 287.315
• Mol file: 1071759-60-8.mol

Synonyms:

Chemical Property of (-)-brunsvigine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-brunsvigine

There total 25 articles about (-)-brunsvigine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C19H21NO4 (355401-66-0) → (-)-brunsvigine (1354-81-0,1071759-60-8)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 2h;

DOI:10.1021/ol016022n

Reference yield: 81.0%

(1S,13S,15R,19S)-17,17-dimethyl-5,7,16,18-tetraoxa-12-azahexacyclo[10.9.1.02,10.04,8.013,21.O15,19]docosa-2,4(8),9,20-tetraene (355401-66-0) → (-)-brunsvigine (1354-81-0,1071759-60-8)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃;

DOI:10.1021/jo801089y

Reference yield: 76.0%

C16H15NO4 (1429055-12-8) → (-)-2-epi-brunsvigine (1429046-69-4) + (-)-brunsvigine (1354-81-0,1071759-60-8)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 2h;

DOI:10.1002/anie.201307324

upstream raw materials:

(1S,13S,15R,19S)-17,17-dimethyl-5,7,16,18-tetraoxa-12-azahexacyclo[10.9.1.0^2,10.0^4,8.0^13,21.O^15,19]docosa-2,4⁽⁸⁾,9,20-tetraene

C₁₆H₁₅NO₄

C₂₂H₂₉NO₆Si

C₂₅H₃₅NO₄Si

Downstream raw materials:

(6R)-8c,9c-bis-(4-bromo-benzoyloxy)-(6at)-5,6a,7,8,9,11-hexahydro-6r,11c-methano-benzo[b][1,3]dioxolo[4',5':4,5]benzo[1,2-e]azepine

(6R)-8c,9c-dimethoxy-6-methyl-(6at)-5,6a,7,8,9,11-hexahydro-6r,11c-methano-benzo[b][1,3]dioxolo[4',5':4,5]benzo[1,2-e]azepinium; picrate

(R)-6-acetyl-8-((1Ξ,3S)-3r,4c-diacetoxy-cyclohexyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline