C₂₈H₄₁N₃O₅

Base Information

• Chemical Name: C₂₈H₄₁N₃O₅
• CAS No.: 1150107-24-6
• Molecular Formula: C₂₈H₄₁N₃O₅
• Molecular Weight: 499.651
• Mol file: 1150107-24-6.mol

Synonyms:

Chemical Property of C₂₈H₄₁N₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₄₁N₃O₅

There total 7 articles about C₂₈H₄₁N₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid (15177-67-0) + 4-(4-cyclohexyl-4-methoxypiperidin-1-yl)benzohydrazide → C28H41N3O5 (1150107-24-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.12.116

Reference yield:

tert-butyl 4-cyclohexyl-4-hydroxypiperidine-1-carboxylate (355380-47-1) → C28H41N3O5 (1150107-24-6)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide

2: trifluoroacetic acid; methoxybenzene / dichloromethane

3: potassium carbonate / dimethyl sulfoxide

4: hydrazine hydrate / tetrahydrofuran; ethanol

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide

With sodium hydride; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.12.116

Reference yield:

ethyl 4-(4-cyclohexyl-4-methoxypiperidin-1-yl)-benzoate → C28H41N3O5 (1150107-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / tetrahydrofuran; ethanol

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.12.116

upstream raw materials:

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid

tert-butyl 4-cyclohexyl-4-hydroxypiperidine-1-carboxylate

cyclohexylmagnesiumchloride

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

C₂₈H₃₉N₃O₃S

C₂₇H₃₇N₃O₂S

C₂₇H₃₇N₃O₃S

trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide