trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide

Base Information

Chemical Name:trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide
CAS No.:1150107-45-1
Molecular Formula:C₂₉H₄₂N₄O₃S
Molecular Weight:526.743
Hs Code.:

Synonyms:trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide

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Chemical Property of trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide

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Technology Process of trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide

There total 10 articles about trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1150107-90-6
C₂₇H₃₇N₃O₃S

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1150107-45-1
trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.12.116

Reference yield:

: 1150107-68-8
C₂₈H₃₉N₃O₃S

: 1150107-45-1
trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; ethanol / tetrahydrofuran

2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With ethanol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.12.116

Reference yield:

: 4-(4-cyclohexyl-4-methoxypiperidin-1-yl)benzohydrazide

: 1150107-45-1
trans-4-{5-[4-(4-cyclohexyl-4-methoxypiperidin-1-yl)phenyl]-1,3,4-thiadiazol-2-yl}-N-methoxy-N-methylcyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide

2: tetraphosphorus decasulfide / tetrahydrofuran

3: potassium hydroxide; ethanol / tetrahydrofuran

4: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With tetraphosphorus decasulfide; ethanol; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.12.116