7-FLUORO-L-TRYPTOPHAN

Base Information

• Chemical Name: 7-FLUORO-L-TRYPTOPHAN
• CAS No.: 138514-97-3
• Molecular Formula: C11H11FN2O2
• Molecular Weight: 222.219
• Hs Code.: 2933998090
• Mol file: 138514-97-3.mol

Synonyms:7-Fluoro-L-tryptophan;L-Tryptophan,7-fluoro;

Chemical Property of 7-FLUORO-L-TRYPTOPHAN

Chemical Property:

• PSA: 79.11000
• LogP: 1.96170

Purity/Quality:

99% ^*data from raw suppliers

7-Fluoro-L-tryptophan 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-FLUORO-L-TRYPTOPHAN

There total 2 articles about 7-FLUORO-L-TRYPTOPHAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

7-fluoro-1H-indole (387-44-0) + L-serin (56-45-1,83245-15-2) → L-7-fluorotryptophan (138514-97-3)

Guidance literature:

With Trp synthase; In aq. phosphate buffer; at 37 ℃; for 48h; pH=7.8; Enzymatic reaction;

DOI:10.1021/acs.jmedchem.0c01536

Reference yield:

3-(1-Acetyl-7-fluoro-1H-indol-3-yl)-2-amino-propionic acid → L-7-fluorotryptophan (138514-97-3)

Guidance literature:

DOI:10.1021/ja00045a004

Reference yield:

L-7-fluorotryptophan (138514-97-3) → Fmoc-D-7F-Trp (1956434-65-3)

Guidance literature:

Multi-step reaction with 3 steps

1: oxygen / aq. buffer / pH 7.4 / Enzymatic reaction

2: ammonia borane / aq. phosphate buffer / 24 h / 25 °C / Enzymatic reaction

3: sodium hydroxide; sodium hydrogencarbonate / water; acetonitrile / 20 °C / pH 8 - 9

With ammonia borane; oxygen; sodium hydrogencarbonate; sodium hydroxide; In aq. phosphate buffer; water; acetonitrile;

DOI:10.1021/acs.jmedchem.0c01536

upstream raw materials:

7-fluoro-1H-indole

L-serin

Downstream raw materials:

Fmoc-D-7F-Trp