2-Bromo-3-phenylpyrazine

Base Information

• Chemical Name: 2-Bromo-3-phenylpyrazine
• CAS No.: 2882-17-9
• Molecular Formula: C₁₀H₇BrN₂
• Molecular Weight: 235.083
• European Community (EC) Number: 866-504-5
• DSSTox Substance ID: DTXSID401313256
• Nikkaji Number: J1.175.390F
• Mol file: 2882-17-9.mol

Synonyms:2-bromo-3-phenylpyrazine;2882-17-9;SCHEMBL8893483;DTXSID401313256;CAA88217;EN300-211410;Z1269233558

Chemical Property of 2-Bromo-3-phenylpyrazine

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 233.97926
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC=CN=C2Br

Technology Process of 2-Bromo-3-phenylpyrazine

There total 3 articles about 2-Bromo-3-phenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenyl-2(1H)-pyrazinone (2882-18-0) → 2-bromo-3-phenylpyrazine (2882-17-9)

Guidance literature:

With phosphorus(V) oxybromide;

DOI:10.1021/ja01591a029

Reference yield:

2-phenyl-3-trimethylsilanyloxy-pyrazine (243472-81-3) → 2-bromo-3-phenylpyrazine (2882-17-9)

Guidance literature:

With phosphorus tribromide; at 170 ℃; for 3h; Yield given;

DOI:10.1002/jhet.5570360334

Reference yield:

→ 2-bromo-3-phenylpyrazine (2882-17-9)

Guidance literature:

entspr. Pyrazin;

upstream raw materials:

3-phenyl-2(1H)-pyrazinone

2-phenyl-3-trimethylsilanyloxy-pyrazine

Downstream raw materials:

3-phenylpyrazine-2-carbonitrile